Sökning: "Maria Fällman"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden Maria Fällman.

  1. 6. Effects of invasin and YopH of Yersinia pseudotuberculosis on host cell signaling

    Författare :Anna Gustavsson; Maria Fällman; Arnoud Sonnenberg; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; β1-integrin; Yersinia pseudotuberculosis; Invasin; YopH; Cell-Matrix Adhesion; Filopodia; Cell Spreading; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Integrins are a large family of membrane-spanning heterodimeric (αβ) receptors that bind to ligands on other cells or to extracellular matrix (ECM) proteins. These receptors mediate bidirectional signaling over the cell membrane to induce signaling cascades mediating functions as cell adhesion, spreading and migration. LÄS MER

  3. 7. Leishmania donovani lipophosphoglycan : effects on actin and phagosomal maturation

    Författare :Åsa Holm; Maria Fällman; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Leishmania donovani promastigotes survive intracellularly in macrophages by inhibiting phagosomal maturation. This ability is conferred by surface lipophosphoglycan (LPG), which is transferred to the host-cell plasma and phagosomal membranes during phagocytosis. LÄS MER

  4. 8. Molecular mechanisms of Yersinia pseudotuberculosis for adaptation and establishment of infection in host tissue

    Författare :A. K. M. Firoj Mahmud; Maria Fällman; Matthew S. Francis; Javier Pizarro-Cerda; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RpoN; T3SS; RNA-Seq; Biofilm; Transcription; Yersinia; Data analysis; ChIP-Seq; biology; biologi;

    Sammanfattning : Bacterial pathogens can evade the host’s immune defence to adapt and establish an infection within the host. Some even slip into a quiescent state to establish themselves without acutely harming the host. Phylogenetically unrelated bacteria can share similar strategies for the establishment of infection and for persistence. LÄS MER

  5. 9. Structural and Functional Aspects of β1 Integrin Signalling

    Författare :Stina Nilsson; Staffan Johansson; Teet Velling; Maria Fällman; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; Integrin; Integrin subunit β1; Integrin activation; Threonine; Phosphorylation; Integrin signalling; FAK; PI3K; MAPK; Cell- och molekylärbiologi;

    Sammanfattning : Integrins are transmembrane glycoproteins primarily mediating interactions of cells with the extracellular matrix. Each receptor is a complex of one α- and one β-subunit with affinity for a diverse set of ligands. LÄS MER

  7. 10. Targeted therapeutic strategies for prostate cancer treatment using novel lipid kinase inhibitors in combination with current drugs

    Författare :Julius Semenas; Jenny L. Persson; Anna Berghard; Maria Fällman; Thomas Grundström; Lukas Kenner; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; bone metastasis; castration-resistant; treatment; precision therapy; PIP5K1A; steroid hormone receptors; cancer stem cells; Oncology; onkologi;

    Sammanfattning : Prostate cancer (PCa) is one of the most common cancer types and the fifth cancer-related cause of death among Western world men.  The sex steroid hormone, androgen and androgen receptor (AR) play important roles in PCa progression. LÄS MER