Sökning: "Mari Enoksson"

Hittade 1 avhandling innehållade orden Mari Enoksson.

1. 1. Modulation of cytochrome c release by mitochondrial redox status and caspase-2

   Författare :Mari Enoksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Apoptosis; cytochrome c release; mitochondria; Glutaredoxin; glutathione;

   Sammanfattning : The release of cytochrome c is an important event during apoptosis, induced by diverse stimuli. Our laboratory has previously proposed that cytochrome c release occurs via a two-step process, involving the detachment of the hemoprotein from its binding to the inner mitochondrial membrane, followed by its release into the cytosol through pores in the outer mitochondrial membrane - an event that is usually triggered by proapoptotic Bcl-2 family proteins, such as Bid, Bax and Bak. LÄS MER