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Visar resultat 1 - 5 av 30 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Deposition and absorption of inhaled drugs

   Författare :Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

   Sammanfattning : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. LÄS MER

3. 2. Aspects of PET-CT in prostate cancer. Protocol optimization, diagnostic accuracy, and dosimetry

   Författare :Mimmi Bjöersdorff; Malmö Nuklearmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET-CT; Prostatacancer; [18F]FCH; [18F]PSMA-1007; optimering; diagnostisk noggrannhet; dosimetri; PET-CT; Prostate Cancer; [18F]FCH; [18F]PSMA-1007; Optimization; Diagnostic accuracy; Dosimetric;

   Sammanfattning : The PET-CT imaging modality is based on positron emission tomography combined with computed tomography. Before a PET-CT examination, a radioactive tracer (also called a radiopharmaceutical) is intravenously injected into the patient. PET technology images the distribution of this tracer element by detecting the decay. LÄS MER

4. 3. Pulmonary imaging with quantification of T1-relaxation and oxygen enhanced MRI

   Författare :Simon Kindvall; Malmö Medicinsk strålningsfysik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Bildtagning med magnetresonans (mangetic resonance imaging eller MRI) är en fascinerande teknik som använder magnetfält och radiovågor för att skapa detaljerade bilder av kroppens innanmäte. Tvärt om mot vad många tror så finns det ingen ”magnetröntgen” i MR-kameran, och därmed ingen skadlig joniserande strålning. LÄS MER

5. 4. Physiology and Pharmacology of GABAA receptors: The Brakes in the Brain

   Författare :Catarina Lindquist; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi; Ion channels; GABA; Inhibition;

   Sammanfattning : Inhibitory neurotransmission in the brain is mostly mediated by gamma-aminobutyric acid type A (GABAA) receptors. These receptors are involved in both phasic inhibition (point-to-point inhibition, synaptic transmission) and tonic inhibition (diffuse form of inhibition, brain homeostasis). LÄS MER

7. 5. Airway mechanics of mice and men

   Författare :Lennart Lundblad; Malmö Klinisk fysiologi och nuklearmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; radiologi; tomografi; tomography; medical instrumentation; Clinical physics; Medicin människa och djur ; Medicine human and vertebrates ; Penh; emphysema; airway resistance; gas conditioning; plethysmography; lung mechanics; Boyle s law; Physiology; medicinsk instrumentering; Klinisk fysiologi; radiology; enhanced pause; pulmonary fibrosis; micro computed tomography; forced oscillation technique; COPD;

   Sammanfattning : In this thesis we explore and further develop several techniques used in the animal laboratory as well as in the clinical setting. In particular, we expand the understanding and usefulness of plethysmographic techniques in small rodents. LÄS MER