Sökning: "Malmö Klinisk Fysiologi"
Visar resultat 1 - 5 av 29 avhandlingar innehållade orden Malmö Klinisk Fysiologi.
1. Deposition and absorption of inhaled drugs
Sammanfattning : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. LÄS MER
2. Aspects of PET-CT in prostate cancer. Protocol optimization, diagnostic accuracy, and dosimetry
Sammanfattning : The PET-CT imaging modality is based on positron emission tomography combined with computed tomography. Before a PET-CT examination, a radioactive tracer (also called a radiopharmaceutical) is intravenously injected into the patient. PET technology images the distribution of this tracer element by detecting the decay. LÄS MER
3. Pulmonary imaging with quantification of T1-relaxation and oxygen enhanced MRI
Sammanfattning : Bildtagning med magnetresonans (mangetic resonance imaging eller MRI) är en fascinerande teknik som använder magnetfält och radiovågor för att skapa detaljerade bilder av kroppens innanmäte. Tvärt om mot vad många tror så finns det ingen ”magnetröntgen” i MR-kameran, och därmed ingen skadlig joniserande strålning. LÄS MER
4. Physiology and Pharmacology of GABAA receptors: The Brakes in the Brain
Sammanfattning : Inhibitory neurotransmission in the brain is mostly mediated by gamma-aminobutyric acid type A (GABAA) receptors. These receptors are involved in both phasic inhibition (point-to-point inhibition, synaptic transmission) and tonic inhibition (diffuse form of inhibition, brain homeostasis). LÄS MER
5. Airway mechanics of mice and men
Sammanfattning : In this thesis we explore and further develop several techniques used in the animal laboratory as well as in the clinical setting. In particular, we expand the understanding and usefulness of plethysmographic techniques in small rodents. LÄS MER