Avancerad sökning

Hittade 1 avhandling som matchar ovanstående sökkriterier.

1. 1. Development and evaluation of analytical techniques for antibodies and antibody-drug conjugates : From verification of conjugation to stability testing

   Författare :Malin Källsten; Jonas Bergquist; Fredrik Lehmann; Sara Lind; Lucia Kovac; Alain Beck; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody-drug conjugates; drug-to-antibody ratio; monoclonal antibody; mass spectrometry; hydrophobic interaction chromatography; sample preparation; aggregation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : Antibody-drug conjugates (ADCs) are becoming increasingly important in oncology. ADCs are inherently heterogeneous analytes. For a successful drug candidate to go through to the clinic, extensive characterization and evaluation of the constructs are necessary. LÄS MER