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  1. 1. T Cell Ontogeny and Effector Functions in Galphai2-deficient Colitis

    Författare :Malin Bjursten; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :colitis; T cells; Galphai2- - mice; thymus; pro-inflammatory cytokines; alpha4 integrin;

    Sammanfattning : Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that affects millions of people worldwide, especially in northern countries such as Sweden, and is characterised by chronic uncontrolled inflammation of the intestinal mucosa. It is the general belief that multiple factors such as genetic and environmental aspects are involved in disease pathogenesis. LÄS MER