Sökning: "Malarone"

Hittade 4 avhandlingar innehållade ordet Malarone.

1. 1. Pharmacokinetics and dynamics of atovaquone and proguanil (Malarone®)

   Författare :Mita M Thapar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Malarone; Atovaquone; proguanil; cycloguanil; pharmacokinetics; drug interactions; pharmacodynamics; resistance;

   Sammanfattning : Malarone® is a fixed dose combination of atovaquone and proguanil and is mainly used for prophylaxis against P. falciparum malaria as an alternative to Lariamo® or chloroquine+proguanil. LÄS MER

3. 2. Development of Analytical Methods for Measurement of Drugs against Malaria in Plasma and Whole Blood

   Författare :Daniel Blessborn; Högskolan Dalarna; []
   Nyckelord :Malaria Method Development Pyronaridine Atovaquone Proguanil Malarone Amodiaquine;

   Sammanfattning : The aim of this thesis was to develop analytical methods for measuring drugs in blood and/or plasma. Solid phase extraction was used for the enrichment and purification of the drugs from the sample matrix. LÄS MER

4. 3. Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria

   Författare :Seema Gupta; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Artemisinin (ART) class of compounds are of special interest due to their rapid onset of action and high activity against multidrug resistant malaria. The major drawback in monotherapy with ART and its derivatives is the high rate of recrudescent infection. LÄS MER

5. 4. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids

   Författare :Niklas Lindegårdh; Karin Markides; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; LC; liquid chromatography; biological samples; SPE; solid phase extraction; validation; antimalarial drugs; amodiaquine; piperaquine; atovaquone; dried blood spots; Analytisk kemi; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. LÄS MER