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1. Protein modification with hydrophobic prenyl groups in malignant cells
Sammanfattning : Mevalonate (MVA) is the key intermediate in the isoprene synthetic pathway leading to the formation of a number of biologically important lipid molecules. It is well known that inhibition of MVA synthesis blocks the cell cycle progression of mammalian cells, a fact suggesting that some isoprenoids derived from MVA are required for cell proliferation. LÄS MER
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