Sökning: "Magdalena Mazurkiewicz"

Hittade 1 avhandling innehållade orden Magdalena Mazurkiewicz.

1. 1. Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy

   Författare :Magdalena Mazurkiewicz; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, cell death, and cell cycle regulation. In comparison to cells in healthy tissues, cancer cells proliferate faster and have increased protein synthesis rate; therefore in order to preserve cellular fitness they are more dependent on UPS than normal cells. LÄS MER