Sökning: "MYCN"
Visar resultat 16 - 20 av 53 avhandlingar innehållade ordet MYCN.
16. TGF-B signaling in Neuroblastoma and Renal Cell Carcinoma
Sammanfattning : The tubular cells of the adult kidney are normally mitotically quiescent, in stark contrast to the massive regenerative capacity of the injured renal epithelium. In Paper I we characterized a new cell population of progenitor cells using ALDH as a selection marker. LÄS MER
17. Metabolism and neural differentiation in childhood neuroblastoma
Sammanfattning : Neuroblastoma is the most common and aggressive extracranial solid tumor during childhood. MYCN-amplification is found in approximately 25 % of all neuroblastoma cases, and is defined as high-risk disease. Development of novel therapeutic approaches focused on MYCN targeting are essential for increased survival these children. LÄS MER
18. Targeting MYC and exploring the role of mitochondrial metabolism in childhood neuroblastoma
Sammanfattning : MYCN is a member of the MYC family of proto-oncogenes, encoding transcription factors (c-MYC, MYCN and L-MYC) that play crucial roles for normal cellular functions and during development. However, the expression of MYC (here referring to c-MYC and MYCN) is found elevated in a large number of human cancers where it is implicated in most aspects of tumorigenesis and correlates to poor clinical outcome. LÄS MER
19. Bringing order to disorder : structural and functional analysis for development of strategies to target MYC
Sammanfattning : Several cellular processes such as cell cycle progression, apoptosis, cell adhesion and motility, cell growth, angiogenesis and differentiation are regulated by the MYC (here MYCN and c-MYC) proto-oncogenes. Elevated expression of MYC is present in a wide range of human tumors including Burkitt´s Lymphoma, neuroblastoma, medulloblastoma, colon cancer and glioblastoma. LÄS MER
20. Novel experimental targeted therapy of neuroblastoma
Sammanfattning : Neuroblastoma, a malignancy of the sympathetic nervous system, is the most common solid extracranial tumor of infancy and is responsible for around 15% of the cancer-related deaths in children. For the entire group the survival has increased over the last decades, but despite today's intense muti-modal therapy the survival of high-risk neuroblastomas lies just around 50%. LÄS MER