Sökning: "MYB"

Visar resultat 16 - 20 av 21 avhandlingar innehållade ordet MYB.

  1. 16. Origin and ontogeny of human lung macrophages

    Författare :Elza Evren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The lung is a vital organ occupied by a large diversity of immune cells due to its close proximity with the external environment. This thesis focuses on a particular type of immune cell: the macrophage. LÄS MER

  3. 17. Regulation of artemisinin biosynthesis in Artemisia annua L

    Författare :Ke Yang; Peter E. Brodelius; Åke Strid; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; regulation of artemisinin biosynthesis; Artemisia annua transcription factors; AaMYB1; wounding treatment; promoter cloning; GC-MS; qPCR; Biokemi; Biochemistry; Mikrobiologi; Microbiology;

    Sammanfattning : Artemisinin and its derivatives are the most powerful medicines against malaria. However,the low annual yield of artemisinin from industry restricts the usage of this effective drug inendemic areas such as Africa. Nowadays the artemisinin industry mainly depends onextractions from Artemisia annua L. LÄS MER

  4. 18. New aspects on retinoic acid induced HL-60 granulocytic differentiation

    Författare :Agnè Kulytè; Tor Olofsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The underlying mechanisms of myeloid cell differentiation are still not entirely elucidated. It is therefore an urgent task to extent the basis for a comprehensive model of granulocytes differentiation. A primary goal for studies has been the identification of differentiation markers. LÄS MER

  5. 19. The role and mechanism of ubiquitin system in innate immune regulation

    Författare :Swarupa Panda; Nelson O. Gekara; Fredrik Elgh; Anna Överby; Geert van Loo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The ubiquitin system; Deubiquitinase; MYSM1; Innate immune regulation Toll-like receptor; RIG-l like receptors; Cytoplasmic DNA receptors; NOD-like receptors; Francisella tularensis; Immune subversion; molekylärbiologi; Molecular Biology;

    Sammanfattning : Pattern-recognition receptors (PRRs) include the cell surface or endosomal membrane localized Toll-like receptors (TLRs) and the cytoplasmic PRRs such as RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and cytoplasmic DNA receptors (CDRs). Triggering of PRRs culminates in the transcriptional induction of pro-inflammatory cytokines and type I interferons (IFNs) that coordinate protection against pathogens but require tight control to avert inflammatory diseases. LÄS MER

  7. 20. Identification of genes and regulators that are shared across T cell associated diseases

    Författare :Danuta R. Gawel; Mikael Benson; Mika Gustafsson; Colm Nestor; Erik Larsson Lekholm; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Genome-wide association studies (GWASs) of hundreds of diseases and millions of patients have led to the identification of genes that are associated with more than one disease. The aims of this PhD thesis were to a) identify a group of genes important in multiple diseases (shared disease genes), b) identify shared up-stream disease regulators, and c) determine how the same genes can be involved in the pathogenesis of different diseases. LÄS MER