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Visar resultat 1 - 5 av 21 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms

   Författare :Marta Persson; Göteborgs universitet; []
   Nyckelord :cancer genetics; fusion oncogenes; chromosome translocation; MYB; NFIB; CRTC1; MAML2; salivary gland; breast; adenoid cystic carcinoma; mucoepidermoid carcinoma; hidradenoma;

   Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER

3. 2. Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors

   Författare :Maryam K. Afshari; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fusion oncogene; MYB; NFIB; PLAG1; HMGA2; adenoid cystic carcinoma; pleomorphic adenoma; targeted therapy;

   Sammanfattning : Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many solid tumors, including salivary gland tumors (SGTs). LÄS MER

4. 3. Gene Expression Profiling of Hereditary Breast Cancer

   Författare :Ingrid Hedenfalk; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-BRCA1 BRCA2; BRCAx; MYB; cDNA microarray; gene expression profiling; tissue microarray; Cytology; oncology; cancerology; Cytologi; cancer; onkologi; BRCA2; Hereditary breast cancer; BRCA1;

   Sammanfattning : [abstract missing].... LÄS MER

5. 4. Investigation of genes and proteins involved in xylan biosynthesis

   Författare :Anders Winzell; Ines Ezcurra; Johan Edqvist; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Populus; xylan biosynthesis; hemicellulose; glycosyltransferase; GT43; IRX; glycoside hydrolase; GH10; Xyn10A; CAZy; transcription factor; MYB; wood formation; secondary cell wall; Arabidopsis; Molecular biology; Molekylärbiologi;

   Sammanfattning : Wood formation or xylogenesis is a fundamental process for so diverse issues as industry, shelter and a sustainable environment. Wood is comprised of secondary xylem, rigid large cells with thick cell walls that are lignified. LÄS MER

7. 5. Functional studies of Mediator in Arabidopsis thaliana and Saccharomyces cerevisiae

   Författare :Nils Elfving; Stefan Björklund; Jesper Svejstrup; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcriptional regulation; chromatin; stress; Pol II; mediator; DREB2A; ZFHD1; MYB-like; Msn2; molekylärbiologi; Molecular Biology;

   Sammanfattning : Mediator has been shown to be essential for regulation of RNA Polymerase II mediated transcription. Mediator functions as an interface between the general transcriptional machinery and a multitude of DNA binding transcriptional regulators, although the molecular mechanism for the process is elusive. LÄS MER