Sökning: "MVA"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet MVA.

  1. 1. Value-based management - positioning of claimed merits and analysis of application

    Författare :Peter W Jönsson; Företagsekonomiska institutionen; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; adoption; management process aspects; objective; performance measurement; strategic planning; remuneration; MVA; EVA; TBR; CFROI; Accounting; TSR; measurement aspects; management accounting constructs; Value-based management; management accounting; Redovisning;

    Sammanfattning : Value-based management has attracted considerable interest among organizations and academics in recent years. Responding to calls for case-based research, this thesis describes, analyses and conceptualizes value-based management as a management accounting construct. While previous research has focused on the measures (eg. LÄS MER

  3. 2. Novel Synthetic Biology Tools for Metabolic Engineering of Saccharomyces cerevisiae

    Författare :Siavash Partow; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast promoter; MVA pathway; Metabolic engineering; Multi-copy plasmid.; Synthetic biology; S. cerevisiae; MEP pathway;

    Sammanfattning : The most well characterized eukaryote model organism Saccharomyces cerevisiae is not only preferred as a microbial cell factory for synthesis of industrial products, e.g. bioethanol, but this eukaryote host system is also defined as a robust scaffold for commercial production of diverse chemicals e.g. LÄS MER

  4. 3. Immune responses induced by immunization with HIV-1 DNA followed by HIV-modified vaccinia virus Ankara with or without recombinant GP140 in healthy Tanzanian individuals

    Författare :Agricola Joachim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A vaccine against HIV is widely considered the most effective and sustainable way of preventing new infections. We previously conducted a phase I/II clinical trial using multi-clade, multigene HIV-DNA priming and boosting with the recombinant modified vaccinia Ankara (HIV-MVA) virus among healthy Tanzanian volunteers (HIVIS03 trial). LÄS MER

  5. 4. Role of dolichyl phosphate, N-linked glycosylation and cell membrane expression of insulin-like growth factor-1 receptor in maintenance of malignant cell growth

    Författare :Anica Dricu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Several studies have demonstrated that mevalonate (MVA) synthesis is required for cell proliferation. The mechanisms underlying MVA-regulated cell growth are still not fully understood. One conceivable mechanism for MVA-dependent cell growth is N-linked glycosylation of growth regulatory proteins. LÄS MER

  7. 5. Protein modification with hydrophobic prenyl groups in malignant cells

    Författare :Magnus Hjertman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mevalonate (MVA) is the key intermediate in the isoprene synthetic pathway leading to the formation of a number of biologically important lipid molecules. It is well known that inhibition of MVA synthesis blocks the cell cycle progression of mammalian cells, a fact suggesting that some isoprenoids derived from MVA are required for cell proliferation. LÄS MER