Sökning: "MVA pathway"

Hittade 5 avhandlingar innehållade orden MVA pathway.

  1. 1. Novel Synthetic Biology Tools for Metabolic Engineering of Saccharomyces cerevisiae

    Författare :Siavash Partow; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast promoter; MVA pathway; Metabolic engineering; Multi-copy plasmid.; Synthetic biology; S. cerevisiae; MEP pathway;

    Sammanfattning : The most well characterized eukaryote model organism Saccharomyces cerevisiae is not only preferred as a microbial cell factory for synthesis of industrial products, e.g. bioethanol, but this eukaryote host system is also defined as a robust scaffold for commercial production of diverse chemicals e.g. LÄS MER

  3. 2. Role of dolichyl phosphate, N-linked glycosylation and cell membrane expression of insulin-like growth factor-1 receptor in maintenance of malignant cell growth

    Författare :Anica Dricu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Several studies have demonstrated that mevalonate (MVA) synthesis is required for cell proliferation. The mechanisms underlying MVA-regulated cell growth are still not fully understood. One conceivable mechanism for MVA-dependent cell growth is N-linked glycosylation of growth regulatory proteins. LÄS MER

  4. 3. Protein modification with hydrophobic prenyl groups in malignant cells

    Författare :Magnus Hjertman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mevalonate (MVA) is the key intermediate in the isoprene synthetic pathway leading to the formation of a number of biologically important lipid molecules. It is well known that inhibition of MVA synthesis blocks the cell cycle progression of mammalian cells, a fact suggesting that some isoprenoids derived from MVA are required for cell proliferation. LÄS MER

  5. 4. Structure and biosynthesis of fungal secondary metabolites : studies of the root rot pathogen Heterobasidion annosum s.l. and the biocontrol fungus Phlebiopsis gigantea

    Författare :David Kälvö; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The root rot pathogen Heterobasidion annosum s.l., i.e. LÄS MER

  7. 5. Importance of insulin-like growth factor-1 receptor and EWS/FLI-1 fusion protein in growth and survival of two different types of neuroectodermal tumor cells

    Författare :Min Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Treatment with comparatively low doses of the 3-hydroxy-3-metylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin caused growth arrest in both melanoma cells and Ewing's sarcoma (ES) cells. In melanoma cells growth inhibition was correlated with a drastic decrease in N-linked glycosylation of the insulin-like growth factor-1 receptor (IGF-1R), which in turn was followed by a decreased expression of IGF-1 binding sites at the cell surface. LÄS MER