Avancerad sökning
Hittade 3 avhandlingar som matchar ovanstående sökkriterier.
1. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria
Sammanfattning : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. LÄS MER
2. Targeting MTHFD1 and MTHFD2 as cancer treatment
Sammanfattning : One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and therefore plays a central role in DNA replication and repair. To sustain rapid proliferation, cancer cells often upregulate their 1C metabolism, including the enzymes MTHFD1 and MTHFD2, as a part of their metabolic rewiring. LÄS MER
3. Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets
Sammanfattning : Altered tumor metabolism has been described as early as the 1920s, but it was only in recent decades that proteomic and metabolomic studies revealed that the ways in which tumors rewire their nutrient and energy pathways are more diverse and have more implications for treatment outcome than previously thought. There is now a great interest in characterizing promising metabolic targets and identifying novel ways by which to exploit them for cancer treatment. LÄS MER
