Sökning: "MSNs"

Visar resultat 6 - 10 av 15 avhandlingar innehållade ordet MSNs.

1. 6. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease

   Författare :Marko Filipović; Jeanette Hellgren Kotaleski; Arvind Kumar; Gilad Silberberg; Ad Aertsen; Andrew Sharott; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; basal ganglia; striatum; medium spiny neurons; subthalamic nucleus; globus pallidus; Parkinson s disease; in vivo; oscillations; spectral analysis; response variability; networks; simulations; modelling; Numerical Analysis; Numerisk analys; Computer Science; Datalogi; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

   Sammanfattning : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. LÄS MER

3. 7. Who, when and how : electrophysiological studies on connectivity of striatal neurons

   Författare :Susanne Natalie Szydlowski; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The nervous system has been studied in many ways and in many different organisms. Organisms that have a brain and mind or a simpler nervous system use it to sense the environment, process this sensory input and make appropriate decisions on how to act or interact with the environment. LÄS MER

4. 8. Untangling Cortico-Striatal Circuitry and its Role in Health and Disease - A computational investigation

   Författare :Jovana Belic; Jeanette Hellgren Kotaleski; Arvind Kumar; Abigail Morrison; Arthur Leblois; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cortico-striatal circuits; levodopa-induced dyskinesia; Parkinson’s disease; effective connectivity; cross-frequency coupling; corticostriatal network; network oscillations; GABAergic transmission. basal ganglia; striatum; cortex; fast spiking interneurons; medium spiny neurons; neuronal avalanches;

   Sammanfattning : The basal ganglia (BG) play a critical role in a variety of regular motor and cognitive functions. Many brain diseases, such as Parkinson’s diseases, Huntington’s disease and dyskinesia, are directly related to malfunctions of the BG nuclei. LÄS MER

5. 9. Structure-Dynamics relationship in basalganglia: Implications for brain function

   Författare :Jyotika Bahuguna; Arvind Kumar; Jeanette Kotaleski; Nicholas Mallet; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computational Modeling; Basal ganglia; network dynamics; Computer Science; Datalogi;

   Sammanfattning : In this thesis, I have used a combination of computational models such as mean field and spikingnetwork simulations to study various sub-circuits of basal ganglia. I first studied the striatum(chapter 2), which is the input nucleus of basal ganglia. LÄS MER

7. 10. Computational Dissection of the Basal Ganglia : functions and dynamics in health and disease

   Författare :Mikael Lindahl; Jeanette Hällgren Kotaleski; Mark Humphries; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computer Science; Datalogi;

   Sammanfattning : The basal ganglia (BG), a group of nuclei in the forebrain of all vertebrates, are important for behavioral selection. BG receive contextual input from most cortical areas as well as from parts of the thalamus, and provide output to brain systems that are involved in the generation of behavior, i.e. the thalamus and the brain stem. LÄS MER