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Visar resultat 1 - 5 av 15 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Modeling receptor induced signaling in MSNs : Interaction between molecules involved in striatal synaptic plasticity

   Författare :Anu G. Nair; Jeanette Hellgren Kotaleski; Omar Gutierrez-Arenas; Upinder S. Bhalla; Pierre Vincent; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatal synaptic plasticity; LTP; Dopamine; Acetylcholine; Synergy; Medium spiny neurons; MSNs;

   Sammanfattning : Basal Ganglia are evolutionarily conserved brain nuclei involved in several physiologically important animal behaviors like motor control and reward learning. Striatum, which is the input nuclei of basal ganglia, integrates inputs from several neurons, like cortical and thalamic glutamatergic input and local GABAergic inputs. LÄS MER

3. 2. Dissecting the intrastriatal neuronal circuitry that regulates direct and indirect striatal projections

   Författare :Henrike Planert; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :basal ganglia;

   Sammanfattning : The basal ganglia (BG) are a group of subcortical nuclei that are interconnected in multiple parallel cortico-BG-thalamocortical loops. They have been implicated in many functions, among them action control and motor learning. The striatum forms the main input nucleus of the BG. LÄS MER

4. 3. Non-linear synaptic integration on dendrites of striatal medium-spiny neuron : a computational study

   Författare :Kai Du; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Striatum is the main input nucleus of basal ganglia. Medium-spiny neurons (MSNs), the principal neurons of the striatum, receive convergent excitatory inputs from cortex and thalamus, thus “gate” the information flow to the basal ganglia. LÄS MER

5. 4. Modeling Biochemical Network Involved in Striatal Dopamine Signaling

   Författare :Anu G. Nair; Jeanette Hellgren Kotaleski; Omar Gutierrez Arenas; Upinder Singh Bhalla; Jakob Kisbye Dreyer; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine signaling; Striatum; Reward learning; Acetylcholine; Mass-action modeling; FRET biosensor; Adenosine; Eligibility trace; Computer Science; Datalogi;

   Sammanfattning : In this thesis, I studied the molecular integration of reward-learning related neuromodulatory inputs by striatal medium-sized projection neurons (MSNs) using mass-action kinetic modeling.It is known that, in reward learning, an unexpected reward results in transient elevation in dopamine (peak) whereas omission of an expected reward leads to transient dopamine decrease (dip). LÄS MER

7. 5. Molecular basis of L-DOPA-induced dyskinesia : studies on striatal signaling

   Författare :Emanuela Santini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Parkinson s disease (PD) is a neurological disorder characterized by tremor, rigidity and bradykinesia. PD is caused by selective degeneration of the dopaminergic neurons, which originate in the substantia nigra pars compacta (SNc) and project to the striatum. LÄS MER