Sökning: "MRTF-A"

Hittade 4 avhandlingar innehållade ordet MRTF-A.

  1. 1. The Extended Role of the Molecular Chaperone CCT

    Författare :Andreas Svanström; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; CCT oligomer; Actin; CCT delta; CCT epsilon; Gelsolin; MRTF-A; Cell morphology;

    Sammanfattning : The oligomeric chaperone CCT is a large ATP-dependent chaperonin that consists of two rings placed back-to-back with eight different paralogous subunits with a size of ~ 55 kDa that sit in each of the two rings. The function of CCT is mainly to fold the abundant proteins actin and tubulin, components of the cytoskeleton. LÄS MER

  3. 2. Profilin : From the Cell Edge into the Nucleus

    Författare :Sara Sadi; Roger Karlsson; Maria Vartiainen; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; profilin; actin; microfilament system; nucleus; SRF; MRTF; MAL; transcription; microtubules; Cell Biology; cellbiologi;

    Sammanfattning : Internal and external signaling dependent changes in cell behavior are directly linked to force-generating remodeling of the actin microfilament system which is juxtaposed to the inside of the plasma membrane. This dynamic filament system is involved in many processes in the cytoplasm and the nucleus of eukaryotic cells. LÄS MER

  4. 3. New insight into myocardin regulation and function in smooth muscle cells

    Författare :Li Liu; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alternative splicing; Contractility; Inflammation; Muscarinic receptor; Myocardin-related transcription factors; Phenotypic modulation; Smooth muscle; SRF; WWTR1; YAP1;

    Sammanfattning : Smooth muscle cells (SMCs) are constituents of hollow inner organs. Their contractile function governs essential physiological functions, such as breathing, eating, blood pressure control, urination, and childbirth. LÄS MER

  5. 4. Transcriptional control in the vascular wall. Actin-responsive coactivators and smooth muscle transcripts

    Författare :Katarzyna Krawczyk; Cellulär biomekanik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cardiovascular disease (CVD) is the leading cause of death globally. In the European Union (EU) alone, CVD accounts for 1.8 million deaths each year. CVD is a group of disorders involving the heart and the blood vessels. LÄS MER