Sökning: "MPTP monkey model"

Hittade 2 avhandlingar innehållade orden MPTP monkey model.

  1. 1. Involvement of non-dopaminergic systems in L-DOPA-induced dyskinsia

    Författare :Daniella Rylander; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; Dyskinesia; L-DOPA; 6-OHDA rat model; MPTP monkey model; glutamate; serotonin; DA.; 5-HT;

    Sammanfattning : Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. LÄS MER

  3. 2. Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease

    Författare :Kioumars Delfani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson s Disease; apoptosis; substantia nigra; dopamine; MPTP; neurogenesis; intracranial transplantation; ATP; PET; stereology; diethyldithiocarbamate; 7-nitroindazole; mouse; squirrel monkey; non- human primate;

    Sammanfattning : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. LÄS MER