Sökning: "MPT"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet MPT.

  1. 1. Improving strategic decisions for real estate investors : Perspectives on allocation and management

    Författare :Sigrid Katzler; Svante Mandell; Inga-Lill Söderberg; Elias Oikarinen; KTH; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Public real estate; private real estate; MPT; time-varying correlation; liquidity; mixed-asset portfolio; real estate portfolio; diversification; outsourcing; Fastigheter och byggande; Real Estate and Construction Management;

    Sammanfattning : Real estate is an attractive asset class in the mixed-asset portfolio due to favorable risk return characteristics and low correlations with other asset classes like stock and bonds. Unlike financial assets, real estate is a physical asset where large lot sizes/indivisibility, heterogeneity, low liquidity and high transaction costs make applying financial models like modern portfolio theory (MPT) challenging. LÄS MER

  3. 2. Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target

    Författare :Magnus Hansson; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; farmakognosi; farmaci; Bioenergetik; Bioenergetics; neuropsykologi; toxikologi; neurofysiologi; Neurologi; Neurology; neurophysiology; neuropsychology; Neurodegeneration; Mitochondria; Brain; Pharmacological sciences; pharmacognosy; pharmacy; Farmakologi; toxicology;

    Sammanfattning : There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. LÄS MER

  4. 3. Calcium-induced mitochondrial permeability transition in CNS-derived mitochondria - Pharmacological aspects of specificity and toxicity in neuroprotection

    Författare :Roland Månsson; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; mitochondria; brain; calcium; respiration; cell death; permeability transition; calcium retention; minocycline; neuroprotection; Debio 025;

    Sammanfattning : Mitochondria are the main site for energy conversion in the cell. Under certain circumstances, such as excess calcium retention or production of reactive oxygen species, a pore forms at contact sites between the outer and the normally impermeable inner mitochondrial membrane. LÄS MER

  5. 4. Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia

    Författare :Michel Ferrand-Drake; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; neuronal death; calpain; caspase; mitochondrial permeability transition; necrosis; apoptosis; cerebral ischemia; hypoglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia Following prolonged disruption of blood flow to the central nervous system (CNS), or energy deprivation by other means, such as hypoglycemia, some cells will inevitably degenerate. It has been, and still is, the subject of considerable debate and intense research on brain ischemia, as to the mode of cell death, i. LÄS MER

  7. 5. Mechanisms of apoptosis induced by a protein complex isolated from human milk : with focus on the role of mitochondria

    Författare :Camilla Köhler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human milk contains a protein complex comprising of a folding variant of human alpha-lactalbumin and oleic acid (C18:1). Both, a milk fraction containing this complex (MAL, for multimeric (alpha- lactalbumin). LÄS MER