Sökning: "MMP-1"

Visar resultat 1 - 5 av 32 avhandlingar innehållade ordet MMP-1.

  1. 1. Effect of Ischaemia-Reperfusion on Rabbit Kidney and Human Brain

    Författare :Jagdish Shivlal Gondalia; Göteborgs universitet; []
    Nyckelord :Free radicals; ischaemia-reperfusion; cell bioenergetics; NMR; ESR; carotid artery stenosis; endarterectomy; allopurinol; acetylcysteine; MMP-1; ICAM-1; MCP-9; oxLDL;

    Sammanfattning : Free radicals are produced in various organs at ischaemia-reperfusion. The final stage in radical damage is lipid peroxidation. We have demonstrated previously that a lipid-soluble antioxidant improves restoration of bioenergetics in rabbit kidneys after ischaemia, as reflected in 31P spectrometry. LÄS MER

  3. 2. Clinical, biochemical and morphological aspects of cervical ripening in the first trimester

    Författare :Nina Vukas Radulovic; Göteborgs universitet; []
    Nyckelord :cervical ripening; misoprostol; nitric oxide; electron microscopy; miscarriage; IL-8; MMP-1; MMP-8; MMP-9;

    Sammanfattning : Background: The uterine cervix has the ability to be transformed from being a rigid organ in non-pregnant women to become a loose structure that dilates and allows passage of the foetus at parturition. This process, cervical ripening, has been described similar to an inflammatory reaction of the extracellular matrix involving activation of inflammatory cytokines, matrix metalloproteinases and breakdown of the collagen framework. LÄS MER

  4. 3. Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts

    Författare :Helena Domeij; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Matrix metalloproteinases; tissue inhibitor of metalloproteinases; gingival fibroblasts; monocytes; periodontal diseases;

    Sammanfattning : Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes collectively responsible for the metabolism of extra cellular matrix components. Disturbance of the physiological balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. LÄS MER

  5. 4. Inflammation and matrix degrading proteases in coronary artery disease

    Författare :Ann Samnegård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myocardial infarction; matrix metalloproteinases; inflammation; polymorphism; haplotype; gender; cytokines;

    Sammanfattning : Coronary artery disease (CAD) is a major cause of morbidity and death in the world today. The underlying process, atherosclerosis, is caused by lipid accumulation and inflammatory processes within the intimal layer of the vessel wall. LÄS MER

  7. 5. Tissue remodelling proteases as prognostic factors in colon and rectal cancer

    Författare :Marcus Langenskiöld; Göteborgs universitet; []
    Nyckelord :extracelluar matrix; survival; staging; colorectal cancer; mucosa; stroma;

    Sammanfattning : Background: Colorectal cancer is the third most common cancer in Sweden and the main treatment is surgery. The TNM classification is the principal staging tool, although insufficient in identifying all patients with poor survival. LÄS MER