Sökning: "MMCP"
Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet MMCP.
1. Neutral proteases of rodent mast cells
Sammanfattning : Mast cells are important effector cells in general as well as in allergic inflammation andin the defence against helminthic parasites and bacteria. Two major populations, withdifferences in tissue distribution, have been identified; connective tissue mast cells andmucosal mast cells. LÄS MER
2. The role of mast cell proteases in allergic disease and apoptosis
Sammanfattning : Mast cells (MCs) are key effector cells in allergic reactions, through the release of a wide variety of granule-stored and de novo synthesized inflammatory mediators. The MC secretory granules contain exceedingly high levels of serglycin proteoglycan and the heparin-binding proteases chymase, tryptase and carboxypeptidase A. LÄS MER
3. Chymotrypsin/trypsin-related serine proteases : A structural, functional and evolutionary analysis
Sammanfattning : Is life possible without proteolytic enzymes? Proteases participate in almost everyaspect of life and they can be found throughout the body and in every cell. Mast cells,together with basophils are, two important effector cells of the immune system. LÄS MER
4. Serglycin-dependent mast cell-specific proteases and their potential interactions with Giardia intestinalis
Sammanfattning : Mast cells are located in mucosal and connective tissues throughout the body where they play important roles in immune reactions towards infections. Mast cell deficiency results in failure of clearance of the non-invasive intestinal protozoan parasite Giardia intestinalis in mice, but the mast cell-driven mechanisms remain poorly understood. LÄS MER
5. The Role of Fc gamma Receptors and Mast Cell Chymase in Autoimmune Arthritis
Sammanfattning : In autoimmune diseases such as rheumatoid arthritis (RA), self-reactive antibodies are present at high levels, which contributes to disease pathogenesis. The antibodies mediate their effect predominantly by binding to Fc gamma receptors (FcγR) on various leukocytes, such as monocytes, macrophages and mast cells, where FcγR ligation leads to cell activation. LÄS MER