Sökning: "MLTU L1"

Hittade 4 avhandlingar innehållade orden MLTU L1.

  1. 1. Viral Control of SR Protein Activity

    Författare :Camilla Estmer Nilsson; Neus Visa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; adenovirus; ASF SF2; dephosphorylation; E4-ORF4; L1; MLTU; PP2A; splicing; SR proteins; vaccinia virus; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : Viruses modulate biosynthetic machineries of the host cell for a rapid and efficient virus replication. One important way of modulating protein activity in eukaryotic cells is by reversible phosphorylation. In this thesis we have studied adenovirus and vaccinia virus, two DNA viruses with different replication stategies. LÄS MER

  3. 2. Regulation of adenovirus alternative pre-mRNA splicing : Functional characterization of exonic and intronic splicing enhancer elements

    Författare :Bai-Gong Yue; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; adenovirus; pre-mRNA splicing; splicing enhancer; MLTU; L1; SR protein; ASF SF2; E. coli; phosphorylation; dephosphorylation; Biokemi; Biochemistry; Biokemi; mikrobiologi; Microbiology;

    Sammanfattning : Pre-mRNA splicing and alternative pre-mRNA splicing are key regulatory steps controlling geneexpression in higher eukaryotes. The work in this thesis was focused on a characterization of thesignificance of exonic and intronic splicing enhancer elements for pre-mRNA splicing. LÄS MER

  4. 3. The Adenovirus L4-33K Protein : A Key Regulator of Virus-specific Alternative Splicing

    Författare :Heidi Törmänen Persson; Göran Akusjärvi; Stefan Schwartz; Marie Öhman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-33K; adenovirus; splicing; phosphorylation; localization; replication centers; L4-22K; MLTU; DNA-PK; DNA-dependent protein kinase; PKA; cAMP-dependent protein kinase; transcription sites; SR protein; Medical Virology; Medicinsk virologi;

    Sammanfattning : Adenoviruses have been extensively studied in the field of gene regulation, since their genes are subjected to a tightly controlled temporal expression during the virus lifetime. The early-to-late shift in adenoviral gene expression distinguishes two completely different programs in gene expression. LÄS MER

  5. 4. The Modular Domain Structure of ASF/SF2: Significance for its Function as a Regulator of RNA Splicing

    Författare :Vita Dauksaite; Göran Akusjärvi; Javier Caceres; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; pre-mRNA splicing; alternative splicing; splicing regulation; SR proteins; ASF SF2; modular domains; adenovirus; MLTU L1; E1A; MS2; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : ASF/SF2 is an essential splicing factor, required for constitutive splicing, and functioning as a regulator of alternative splicing. ASF/SF2 is modular in structure and contains two amino-terminal RNA binding domains (RBD1 and RBD2), and a carboxy-terminal RS domain. LÄS MER