Sökning: "MIR"

Visar resultat 6 - 10 av 163 avhandlingar innehållade ordet MIR.

  1. 6. The Role of miRNA in Neurogenesis and Cell Specification

    Författare :Malin Åkerblom; Molekylär neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miRNA; microRNA; miR-124; miR-9; miR-125; adult neurogenesis; neural stem cells; cell specification; microglia; lentiviral vectors; olfactory bulb; olfactory bulb interneurons;

    Sammanfattning : Only a few decades ago, it was generally believed that gene expression was controlled in a unidirectional way, i.e. DNA was transcribed into RNA, which simply acted as a messenger molecule used to produce the protein that executed cellular functions. LÄS MER

  3. 7. Translational and functional analyses of microRNAs in prostate cancer

    Författare :Olivia Larne; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; microRNA; PSA; androgen receptor; miR-96; miR-145; miR-183;

    Sammanfattning : The aims of this thesis were to identify microRNAs (miRNAs) with prostate cancer prognostic and diagnostic potential, to discover miRNAs with therapeutic capacity against prostate cancer, and to investigate if prostate specific antigen (PSA) is miRNA regulated. Prostate cancer is a globally spread disease with low mortality, but some patients develop an aggressive lethal form of prostate cancer with severe morbidity. LÄS MER

  4. 8. MicroRNAs in HER2-Amplified Breast Cancer

    Författare :Inga Newie; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miR-21; PAPD5; Breast Cancer; miR-4728; microRNA; ERBB2 HER2;

    Sammanfattning : Background: Breast cancer is the most common female malignancy and the leading cause of cancer-related deaths worldwide. Targeted therapy against the main biomarkers estrogen receptor alpha (ER) and human epidermal growth factor receptor 2 (HER2/ERBB2) have greatly improved mortality rates, but ab initio or acquired therapy resistance is common. LÄS MER

  5. 9. Deregulation and editing of microRNAs in metastatic prostate cancer

    Författare :Gjendine Voss; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; bone metastasis; microRNA; RNA editing; A-to-I editing; ADAR; miR-96; miR-379;

    Sammanfattning : Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. LÄS MER

  7. 10. Glioma as an Ecosystem : Studies of Invasion, Onco-miR Addiction and Mast Cell Infiltration

    Författare :Jelena Põlajeva; Bengt Westermark; Ingemar Ernberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; mast cell; miR-21; RAP1; CXCL12; SOX2;

    Sammanfattning : Despite recent advances in oncology and extensive research efforts, gliomas remain essentially incurable. Glioblastoma multiforme (GBM, WHO grade IV) is the most common glioma and may arise de novo or progress from a lower-grade lesion. GBM is characterized by invasive growth, aberrant angiogenesis and necrosis. LÄS MER