Sökning: "MHC-I"

Visar resultat 6 - 10 av 28 avhandlingar innehållade ordet MHC-I.

  1. 6. MHC class I - Peptide binding and complex stability

    Författare :Elna Follin; Antigen presentation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The major histocompatibility class I (MHC-I) genes are highly polymorphic and the proteins that they encode play a crucial role in both the innate and the adaptive immune response. A MHC-I molecule consists of three parts, one polymorphic heavy chain, one invariant light chain, β2-microglobulin and a peptide of usually between 8-11 amino acids in length. LÄS MER

  3. 7. MHC polymorphism in a songbird : Fitness, mate choice, and sexual conflict

    Författare :Jacob Roved; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; MHC diversity; MHC haplotypes; sexually antagonistic selection; costs of immune responses; adaptive immunity; great reed warbler; songbird;

    Sammanfattning : Sex differences in immune responses have been observed across a wide range of animal species, with the generaltendency that males have weaker immune responses than females. These differences are at least partly caused by immune-regulating effects of sex hormones, and have been associated with an increased prevalence of autoimmune disorders in females and with a general tendency for males to be parasitized more often than females. LÄS MER

  4. 8. Binding and immunogenicity of MHC class-I specific peptides and glycopeptides

    Författare :Ussama M Abdel-Motal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Short synthetic MHC class I (MHC-I) Db and Kb binding peptides were found to be strongly immunogenic and capable of inducing virus-specific cytotoxic T lymphocyte (CTL) responses. Restimulation of primed splenocytes with a low peptide concentration generated optimal CTL responses. LÄS MER

  5. 9. Dendritic cell interactions with Gram negative bacteria

    Författare :Mattias Svensson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycology; virology; Major histocompatibility complex molecules; Dendritic cells; Gram negative bacteria; Antigen processing; Antigen presentation; bacteriology; Microbiology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : The interaction between murine bone marrow-derived dendritic cells (DC) and the Gram negative bacteria Salmonella typhimurium and Escherichia coli have been characterised. These studies showed that DC phagocytosed and processed S. typhimurium and E. LÄS MER

  7. 10. NK cells and missing self recognition : genetic control, mhc class i dependent education and potential use in cancer therapy

    Författare :Stina L Wickström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : NK cells belong to the innate immune system and are important in the defense against virus infections and malignant cells. They mediate their effector functions via release of cytotoxic granules and by cytokine production which can influence the status of other (immune) cells. LÄS MER