Sökning: "MHC-I"

Visar resultat 16 - 20 av 28 avhandlingar innehållade ordet MHC-I.

  1. 16. Immunity and immunosuppression in the tumor-host interaction

    Författare :Max Petersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumors; MHC class 1; natural processed peptides; T cells; NK cells; IFN-[gamma]; IL-10; TAP;

    Sammanfattning : With the advent of new methods in molecular biology and in peptide isolation, a number of tumor-associated antigens and their epitopes have been identified and characterized. However, tumors often grow progressively evolving different mechanisms of immune escape, resulting in resistance to MHC class I-restricted tumor-specific T cells. LÄS MER

  3. 17. Presentation of Salmonella antigens by dendritic cells

    Författare :Ulf Yrlid; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; antigen processing and presentation; Dendritic cells; Salmonella; transplantation; Immunologi; serologi;

    Sammanfattning : This study investigates the interaction between dendritic cells (DC) and the Gram negative intracellular bacterium Salmonella typhimurium. Using in vitro and in vivo approaches, the capacity of DC to directly and indirectly present antigens from Salmonella-infected cells, cytokine production by infected DC, and activation of bacteria-specific T cells was analyzed. LÄS MER

  4. 18. Immunogene Therapy of Bladder Carcinoma : A Preclinical Study

    Författare :Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Immunotherapy; Gene therapy; Immunogene therapy; CD40L; Bladder carcinoma; Onkologi; Oncology; Onkologi; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : This thesis comprises studies on murine and human models of bladder carcinoma with the aim to develop novel immunogene therapies. On the basis of the results presented in this thesis, a clinical trial is underway. The potential of activating the immune system to combat cancer has long intrigued immunologists. LÄS MER

  5. 19. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells

    Författare :Alexandra Gabriela Barros Ferreira; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell Reprogramming; Cancer cells; Tumor Antigen-presenting Cells; immunotherapy;

    Sammanfattning : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. LÄS MER

  7. 20. Immunity to Salmonella infection

    Författare :Cecilia Johansson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; cytokines; antigen presentation; liver; dendritic cells; Salmonella; gram negative bacteria;

    Sammanfattning : The immune system has several strategies to combat infections. The present study investigates various aspects of the interaction between Gram negative bacteria, particularly Salmonella, and antigen presenting cells (APC). Salmonella is an intracellular bacterium infecting mice and man. LÄS MER