Sökning: "MHC-I"

Visar resultat 11 - 15 av 28 avhandlingar innehållade ordet MHC-I.

1. 11. NK cell education and adhesion molecules : implications for immunotherapy

   Författare :Arnika Kathleen Wagner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : NK cells have a key role in immune surveillance. They detect aberrant expression of stressinduced molecules and MHC class I molecules with an array of activating and inhibitory receptors. LÄS MER

3. 12. Structural bases for MHC class I peptide selection and neoepitope formation

   Författare :Ida Hafstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : One task of the immune system is to distinguish between healthy cells and altered cells due to viruses or cancers. To achieve this CD8+ T-cells are constantly monitoring the Major histocompatibility class I (MHC-I) complexes expressed on all nucleated cells in the body. LÄS MER

4. 13. MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells

   Författare :Adil Doganay Duru; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats by scanning a repertoire of peptide epitopes presented by major histocompatibility complex (MHC) molecules. LÄS MER

5. 14. Studies on neuronal signaling in the hippocampus related to development, pathogenesis and treatment of mood disorders

   Författare :Nermin Sourial-Bassillious; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hippocampus;

   Sammanfattning : The hippocampus is a central organ in the brain which is interconnected with different cortical regions and plays an important role in memory and learning processes. The anatomical position of the hippocampus together with the special sensitivity of its neurons renders it vulnerable to brain injury. LÄS MER

7. 15. Elicitation and enhancement of T and B cell responses

   Författare :Hannes Uchtenhagen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The Major histocompatibility complex class I (MHC-I) has been characterized in such great depth that a number of its key properties are well understood and part of its behavior can even be predicted. It is therefore intriguing that the impact of small epitope modifications on immunogenicity and the elicitation of T-cell repertoires remain often unpredictable and full of surprises. LÄS MER