Sökning: "MHC-I"

Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet MHC-I.

  1. 1. The MHC genes: variation and impact on life-history traits in house sparrwos

    Författare :Maria Karlsson; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MHC-I; house sparrow; 454-amplicon sequencing; cDNA; functional clustering; trans-species evolution; nestling survival; mate-choice;

    Sammanfattning : In birds the major histocompatibility complex (MHC) organization differs both among and within orders. Galliformes often have simple arrangements with few transcribed MHC genes whilst many songbirds (Passeriformes) have a complex arrangement with many MHC genes and also presence of pseudo-genes. LÄS MER

  3. 2. Avian MHC : Characterization and expression patterns of classical and non-classical MHC-I genes

    Författare :Anna Drews; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MCH class I; Classical genes; Non-classical genes; Expression; Passerine birds;

    Sammanfattning : The function of the vertebrate immune system is to enable recognition and elimination of microorganisms that can cause harm (pathogens). A key component in adaptive immunity is the major histocompatibility complex (MHC) that codes for molecules with antigen presentation function. LÄS MER

  4. 3. Natural killer cell education under conditions of perturbed sensing of MHC : studies in MHC-I mosaic and chimaeric mice

    Författare :Sadia Salam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are innate lymphocytes that play a role in infections, tumours and transplantation. Their activating and inhibitory receptors sense cell surface ligands on potential target cells. LÄS MER

  5. 4. MHC diversity and expression in a songbird : Temporal and transgenerational variation

    Författare :Samantha Mellinger; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MHC diversity; MHC-I gene expression; songbirds; genome assembly; amplicon HTS; temporal variation; family data; great reed warbler Acrocephalus arundinaceus ;

    Sammanfattning : The immune system is of central importance to clear-off pathogens in order to keep an organism healthy. In vertebrates, the Major Histocompatibility Complex (MHC) is a genomic region that holds key genes involved in adaptive immunity and in particular in the antigen presenting process. LÄS MER

  7. 5. Processing and presentation of exogenous antigen by dendritic cells

    Författare :Liying Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DC; vesicular MHC-I processing; Adenosine; CD 1 d; TACA;

    Sammanfattning : Dendritic cells (DC) play a key role in the immune system. In this thesis, we have investigated and characterized pathways for the processing and presentation of exogenous OVA on MHC-I ("cross-presentation") and how these were influenced by the purine nucleoside Adenosine (Ado), an immune regulator that accumulates to high concentrations at sites of inflammation and tumor growth. LÄS MER