Sökning: "MEDICINE Physiology and pharmacology"

Visar resultat 6 - 10 av 24 avhandlingar innehållade orden MEDICINE Physiology and pharmacology.

1. 6. Aspects of aqueous humor dynamics : Studies in vivo and in vitro

   Författare :Maria Samuelsson-Almén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Aqneous humor flow; intraocular pressure; adenylate cyclase; nonpigmented ciliary epithelium; pituitary adenylate cyclase-activating polypeptide; vasoactive intestinal polypeptide; dopamine; prostaglandin; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

   Sammanfattning : The purpose of the present investigation was to study the effects of PGF2α-l-isopropylester, some neuropeptides, and pharmacological agents on aqueous humor dynamics and intraocular pressure (IOP) in vivo and on adenylate cyclase activity in the nonpigmented ciliary epithelium (NPE) in vitro.Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) caused a dose-dependent increase in cAMP formation, indicating that the NPE contains receptors for PACAP and VIP coupled to adenylate cyclase activation. LÄS MER

3. 7. Retinal glucose metabolism and blood flow : Effects of photic stimulation

   Författare :Lin Wang; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; blood flow; darkness; flicker; glucose oxidation; glycolysis; lactate; light; nitric oxide; optic nerve; retina; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

   Sammanfattning : Retinal glucose metabolism was investigated under different light conditions in cats,pigs and rabbits. Glycolysis and glucose oxidation in the outer and inner parts of theretina were assessed by determining arteriovenous concentration differences foroxygen, glucose and lactate, as well as local blood flow. LÄS MER

4. 8. Immunopathogenesis of schistosomiasis mansoni : Immunity and pathology in a primary and a secondary infection following chemotherapy in the mouse and the baboo models

   Författare :Idle Omar Farah; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Baboon; BALB c mice; Chemotherapy; Cytokines; Fibrosis; Granuloma; Modulation; Pathology; Reinfection; Schistosoma mansoni; Th1; Th2; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Medicine; medicin;

   Sammanfattning : This thesis describes a series of experiments aimed at elucidating the mechanisms ofimmunity and pathology elicited by both a primary infection and a reinfection exposure toSchistosoma mansoni following chemotherapy. The effects of a single large cercarial doseand a cumulatively equivalent dose, administered as multiple small doses are compared. LÄS MER

5. 9. Studies on stress in African green monkeys (Cercopithecus aethiops) : Stress associated cortisol and prolactin levels, lymphocyte modulation and pathological changes in adrenal cortex, stomach and hippocampus in the African green monkey (C. aethiops)

   Författare :Mbaruk Abdalla Suleman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; adrenal cortex; capture; confinement; cortisol; husbandry; housing; hippocampus; lymphocytes; prolactin; stomach; stress; wild; African green monkeys; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

   Sammanfattning : African green monkeys (AGMs) are highly susceptible to captivity-induced stress. An investigation of spontaneous deaths of laboratory confined AGMs at the Institute of Primate Research, Nairobi, Kenya over a period of 7.5 years documented mild to severe gastric mucosal erosions and ulcers in 83 of 260 (32%) necropsies. LÄS MER

7. 10. Brain glycine receptors as a common target for alcohol and the relapse-preventing drug acamprosate - a preclinical study

   Författare :Pei Pei Chau; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcoholism; Acamprosate; Glycine receptor; Preclinical study; Dopamine; Ethanol;

   Sammanfattning : Alcohol abuse and dependence make up the most prevalent categories of substance use disorders in the world. Converging evidence from the current research group has identified two receptor populations, the glycine (GlyRs) and nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system, as two potentially important targets for the development of new medication to treat alcohol dependence. LÄS MER