Sökning: "MEDICIN Kemi Klinisk kemi"

Visar resultat 1 - 5 av 221 avhandlingar innehållade orden MEDICIN Kemi Klinisk kemi.

1. 1. Mutant superoxide dismutase-1-caused pathogenesis in amyotrophic lateral sclerosis

   Författare :Daniel Bergemalm; Stefan Marklund; Thomas Brännström; Peter Andersen; Caterina Bendotti; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; mitochondria; proteome; transgenic mice; inclusion; Clinical chemistry; Klinisk kemi; biokemi; Biochemistry; neurologi; Neurology; Clinical Chemistry; klinisk kemi; patologi; Pathology;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects people in their late mid-life, with fatal outcome usually within a few years. The progressive degeneration of neurons responsible for muscle movement (motor neurons) throughout the central nervous system (CNS) leads to muscle wasting and paralysis, and eventually affects respiratory function. LÄS MER

3. 2. Characterization of IgY for Oral Immunotherapy and Prevention of Pseudomonas aeruginosa Infections in Cystic Fibrosis Patients

   Författare :Elin Nilsson; Anders Larsson; Jane Burns; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; Clinical Chemistry; klinisk kemi;

   Sammanfattning : Chicken antibodies, commonly referred to as IgY, have several properties that make them suitable for oral treatment of infections and there is essentially no risk for development of resistance. The overall aims of this thesis were to investigate Anti-Pseudomonas IgY as prophylaxis against infections with Pseudomonas aeruginosa for cystic fibrosis (CF) patients and to characterize the antibody treatment. LÄS MER

4. 3. Some Characteristics of Human Prostasomes and Their Relationship to Prostate Cancer

   Författare :Göran Ronquist; Anders Larsson; Lena Carlsson; Alicia Llorente; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostasomes; prostate; prostate cancer; clusterin; antibodies; metastasis; exosomes; PC-3 cells; DNA vehicles; gene therapy; immunoblotting; mass spectrometry; agarose gel electrophoresis; vertebral metastasis.; Clinical chemistry; Klinisk kemi; Clinical Chemistry; klinisk kemi;

   Sammanfattning : Background: The secretory epithelial cells of the prostate gland use sophisticated vehicles named prostasomes to relay important information to sperm cells in semen. This prostasome-forming and secretory ability of the epithelial cells is also preserved in poorly differentiated prostate cancer cells. LÄS MER

5. 4. Sources of preanalytical error in primary health care : implications for patient safety

   Författare :Johan Söderberg; Christine Brulin; Ewa Idvall; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood specimen collection; haemolysis; medical errors; phlebotomy; preanalytical; primary health care; quality indicators; quality of health care; questionnaires; specimen handling; Clinical chemistry; Klinisk kemi; medicin; Medicine;

   Sammanfattning : Background Venous blood tests constitute an important part in the diagnosis and treatment of patients. However, test results are often viewed as objective values rather than the end result of a complex process. This has clinical importance since most errors arise before the sample reaches the laboratory. LÄS MER

7. 5. Misfolded superoxide dismutase-1 in amyotrophic lateral sclerosis

   Författare :Per Zetterström; Stefan L Marklund; Lawrence J. Hayward; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; protein misfolding; SOD1 conformation; disulfide-reduced; transgenic mice; cerebrospinal fluid; protein-protein interaction; antibodies; Clinical chemistry; Klinisk kemi; Clinical Chemistry; klinisk kemi;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a disease in which the motor neurons die in a progressive manner, leading to paralysis and muscle wasting. ALS is always fatal, usually through respiratory failure when the disease reaches muscles needed for breathing. Most cases are sporadic, but approximately 5–10% are familial. LÄS MER