Sökning: "MC4R"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet MC4R.

  1. 1. Genetic Analysis of Quantitative Traits Using Domestic Animals : A Candidate Gene and Genome Scanning Approach

    Författare :Hee-Bok Park; Leif Andersson; Stefan Marklund; Robert Fredricksson; Holger Luthman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Domestication; horse; pig; chicken; quantitative traits; candidate gene; genome scan; PRKAG3; MC4R; selection experiment; growth; correlated response; metabolic disorders; Quantitative Trait Loci; linkage; single nucleotide polymorphisms; Genetik; Clinical genetics; Klinisk genetik;

    Sammanfattning : Domestication has led to genetic changes that affect quantitative traits in farm animals. Both candidate gene analysis using association tests and genome scans based on linkage analysis have been performed to understand the molecular basis underlying quantitative genetic variation in horses, pigs and chickens. LÄS MER

  3. 2. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r

    Författare :Viveka Dolby; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteiner; enzymologi; Proteins; melanocortin 4 receptor; GPCR; purification; Expression; membrane proteins;

    Sammanfattning : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. LÄS MER

  4. 3. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors

    Författare :Malin C Lagerström; Helgi B. Schiöth; Robert Fredriksson; Anthony J. Harmar; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Classification; Structure; Pharmacology; Evolution; G protein-coupled receptor; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. LÄS MER

  5. 4. Genetic epidemiological aspects of obesity and related traits. Human studies in Swedish and North-American cohorts

    Författare :Peter Jacobson; Göteborgs universitet; []
    Nyckelord :Obesity; candidate genes; metabolic syndrome; resting metabolic rate; respiratory quotient; assortative mating;

    Sammanfattning : Aims: To investigate two obesity candidate genes, the melanocortin-4 receptor (MC4R) and the adiponectin hormone (APM1), by screening their genomic sequences. To search the human genome for quantitative trait loci (QTLs) related to resting metabolic rate (RMR), and respiratory quotient (RQ). LÄS MER

  7. 5. QTL Analysis in the Pig : From the Identification of Quantitative Trait Loci to the Understanding of Molecular Mechanisms

    Författare :Ellen Markljung; Leif Andersson; Göran Andersson; Göran Hjälm; Stefan Marklund; Holger Luthman; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Domestic pigs have become very different form the wild ancestors they originate from. Selection for muscle growth and meat quality has made the pig a good model for genetic studies of muscle development.The first part of this thesis presents a genome-wide scan for quantitative trait loci (QTL) in a cross between Landrace and Hampshire pigs. LÄS MER