Sökning: "MBD"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet MBD.

  1. 1. Designing Routines for Industrial Digitalization

    Författare :Yunchen Sun; Fredrik Tell; Jan Lindvall; Fleur Deken; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Organizational routines; Routine dynamics; Routine design; Digital materiality; Process ontology; Process study; Digital thread; PLM; MBD; Gas turbines; Business Studies; Företagsekonomi;

    Sammanfattning : Industrial digitalization and its promises propel manufacturing firms to pursue digital reality. When changing ways of working, organizational actors often introduce digital artifacts to create a preferred situation where digital technology creates and shapes physical reality. LÄS MER

  3. 2. Aircraft Systems Modeling : Model Based Systems Engineering in Avionics Design and Aircraft Simulation

    Författare :Henric Andersson; Petter Krus; Olof Johansson; Fredrik Berglund; Linköpings universitet; []
    Nyckelord :MBSE; MBD; Avionics; Simulation; TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : Aircraft developers like other development and manufacturing companies, are experiencing increasing complexity in their products and growing competition in the global market. One way to confront the challenges is to make the development process more efficient and to shorten time to market for new products/variants by using design and development methods based on models. LÄS MER

  4. 3. The role of fibroblast growth factor-23 in chronic kidney disease-mineral and bone disorder

    Författare :Majd A. I. Mirza; Tobias Larsson; Tilman Drüeke; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FGF23; FGF-23; CKD; CKD-MBD; cardiovascular disease; vascular function; atherosclerosis; hypertrophy; LVMI; LVH; fractures; bone; fat mass; obesity; apolipoproteins; cholesterol; lipids; Kidney diseases; Njursjukdomar; Cardiovascular medicine; Kardiovaskulär medicin; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Fibroblast growth factor-23 (FGF23) was initially identified as the causative factor of autosomal dominant hypophosphatemic rickets. Further studies confirmed that FGF23 is predominantly expressed in the osteocytes and osteoblasts of bone and that circulating FGF23 acts on the kidney to inhibit renal phosphate reabsorption and 1,25(OH)2D3 hydroxylation. LÄS MER

  5. 4. Causes and consequences of temporomandibular joint diseases

    Författare :Adrian Salinas Fredricson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Temporomandibular joint disorders (TMJD), a subgroup of Temporomandibular disorders (TMD), has a multifactorial etiology with still largely unknown pathophysiology. Although many risk factors have been proposed, few population-based studies have been conducted. LÄS MER

  7. 5. Determining the effects of regulatory parameters on the structural dynamics of P-type ATPase membrane transporters

    Författare :Fredrik Orädd; Magnus Andersson; Magnus Wolf-Watz; Marco Cammarata; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein dynamics; regulation; time-resolved x-ray solution scattering; MD simulation; membrane protein; P-type ATPase; SERCA; CopA; HMA4; adenylate kinase; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : Proteins are macromolecular machines with roles in all cellular activities and structures. The functional properties of each protein is the result of its combination of 3D-structure and inherent dynamics, and a wealth of structural and dynamic mechanisms have evolved to regulate protein activity. LÄS MER