Sökning: "MAPKs"

Visar resultat 6 - 10 av 19 avhandlingar innehållade ordet MAPKs.

  1. 6. Effects of Ischaemia on the Neuroretina and Retinal Blood Vessels

    Författare :Bodil Gesslein; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein kinase C; tumor necrosis factor; mitogen-activated protein kinases; pig; blood vessels; mfERG; Retinal ischaemia; vascular endothelial growth factor; hypoxia-inducible factor;

    Sammanfattning : Identification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. LÄS MER

  3. 7. Modulation of hormone signaling by cadmium : from molecular mechanisms to health implications

    Författare :Imran Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cadmium is a toxic metal classified as human carcinogen and ubiquitously found in our environment mainly from anthropogenic activities. Exposure to cadmium has been associated with increased risk of certain hormone-dependent cancers in humans, and the metal has been proposed to possess endocrine disruptive properties by mimicking the physiological actions of estrogens. LÄS MER

  4. 8. C-peptide structural and functional relationships studied by biosensor technology and mass spectrometry

    Författare :Ermias Melles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Proinsulin C-peptide; biosensor; mass spectrometry;

    Sammanfattning : Proinsulin C-peptide has a number of biological activities and receives interest focusing on the therapeutic potential as a candidate for future co-replacement therapy with insulin in type 1 diabetes. Based on conservation results from comparisons of 22 mammalian proinsulin variants, analogs were constructed for studies of phosphorylation of mitogenactivated protein kinases (MAPKs) in Swiss 3T3 fibroblasts. LÄS MER

  5. 9. MAPK-associated proteins in Arabidopsis thaliana

    Författare :Carolin Sörensson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PHS2; stomata; signalling; Arabidopsis thaliana; MKS80; MAPK;

    Sammanfattning : Abstract Mitogen-Activated Protein Kinases (MAPKs) are signalling proteins that are highly conserved among eukaryotes. They are involved in many biological pathways including cell differentiation and response to different stress situations. LÄS MER

  7. 10. Regulation and physiological role of tyrosine hydroxylase phosphorylation in the striatum

    Författare :Niklas Lindgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tyrosine hydroxylase (TH) catalyses the conversion of tyrosine to DOPA and is the rate- limiting enzyme in the biosynthesis of catecholamines, a group of neurotransmitters involved in various brain functions. Short-term regulation of TH activity is achieved by phosphorylation of the protein's regulatory domain at three seryl residues in positions 19, 31 and 40. LÄS MER