Avancerad sökning

Visar resultat 1 - 5 av 19 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Host cell responses to Helicobacter pylori secreted factors

   Författare :Raquel Garcia Lobato Tavares; Sushil Kumar Pathak; Åsa Sjöling; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter pylori; Secreted proteins; Host cell responses; Macrophages; Apoptosis; Pro-inflammatory cytokines; MAPKs; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : The infection of the human gastric mucosa by the bacterium Helicobacter pylori can lead to the development of gastritis, gastroduodenal ulcers, and cancer. The factors that determine disease development in a small percentage of infected individuals are still not fully understood. LÄS MER

3. 2. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1

   Författare :Ulrik Fried; Institutionen för laboratoriemedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nerve cells; SH-SY5Y; muscarinic receptors; MAPKs; PKC; gene expression; jun; Activating Protein-1; Alcohol; ethanol; CRABP-I; Clinical chemistry; Klinisk kemi;

   Sammanfattning : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. LÄS MER

4. 3. Glucose, Palmitate and Apolipoprotein CIII-induced Effects on Insulin-Producing β-cells

   Författare :E-ri Maria Sol; Peter Bergsten; Noel Morgan; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : Background and aims: Type 2 diabetes mellitus results from complex interplay between genetic predisposition and environmental factors that together promote impairment of insulin-producing β-cells. Elevated levels of glucose, fatty acid palmitate and apolipoprotein CIII (apoCIII) are implicated in this process. LÄS MER

5. 4. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death

   Författare :Dariush Mokhtari; Nils Welsh; Michael Welsh; Anders Tengholm; Shanta Persaud; Uppsala universitet; []
   Nyckelord :Cell biology; MEKK-1; JNK; human islets; β-cells; siRNA; apoptosis; cell death; MAPK; nitric oxide; cytokines; streptozotocin; c-Rel; NF-κB; Cellbiologi;

   Sammanfattning : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. LÄS MER

7. 5. The role of glucocorticoid receptors and mitogen-regulated protein kinases in the cochlea

   Författare :Inna Meltser; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hearing loss induced by acoustic trauma is a common handicap for the human population. Acoustic trauma triggers a cascade of changes in the cochlea such as a direct mechanical damage of sensory hair cells, biochemical disturbances including reactive oxygen and nitrogen species generation, release of pro-inflammatory cytokines and exitotoxicity. LÄS MER