Sökning: "MAO-B"
Visar resultat 11 - 13 av 13 avhandlingar innehållade ordet MAO-B.
11. Deuterium-L-DOPA : a novel means to improve treatment of Parkinson's disease
Sammanfattning : L-DOPA, the precursor of dopamine, is administered to restore dopamine deficiency in Parkinson´s disease (PD) patients. L-DOPA initially provides a sustained symptomatic relief with superior efficacy as compared to other treatments, while long term treatment is complicated by the gradual emergence of troublesome motor complications i.e. LÄS MER
12. Cyanide and central nervous system : a study with focus on brain dopamine
Sammanfattning : The brain is a major target site in acute cyanide intoxication, as indicated by several symptoms and signs. Cyanide inhibits the enzyme cytochrome oxidase. This inhibition causes impaired oxygen utilization in all cells affected, severe metabolic acidosis and inhibited production of energy. LÄS MER
13. Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease
Sammanfattning : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. LÄS MER