Sökning: "MAO-B"
Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet MAO-B.
1. The Relation between Serotonergic Biomarkers and Behaviour : – studies on human primates, non-human primates and transgenic mice
Sammanfattning : Rationale: The serotonergic system is involved in the modulation of emotion and plays an important role for personality and vulnerability for psychiatric disorders. In the papers included in this thesis, we investigate three biological factors that have been studied in relation to psychiatric symptoms: Platelet monoamine oxidase B (MAO-B) activity, and variations in the MAO-A and the serotonin transporter (5HTT) genes. LÄS MER
2. Serotonergic aspects on high consumption of alcohol in humans. Experimental and clinical studies
Sammanfattning : In animal studies an association between alcohol intake and central serotonergic function has been demonstrated. There are also evidence for altered serotonergic neurotransmission in subgroups of alcohol-dependent subjects. LÄS MER
3. Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B)
Sammanfattning : Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the treatment of psychiatric and neurological disorders. LÄS MER
4. Attention-deficit/hyperactivity disorder and disruptive behavior disorders in adolescence related to levels of platelet MAO-B and polymorphisms in two candidate genes
Sammanfattning : Background: Attention-Deficit/Hyperactivity Disorder (ADHD) and Disruptive Behavior Disorders (DBD) (including Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD)), are common developmental and behaviour diagnoses among adolescents. Several of their symptoms, have been linked to genotypes (e.g. LÄS MER
5. Isotopes as Mechanism Spies : Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects
Sammanfattning : This thesis concerns the study of reaction mechanisms by means of kinetic isotope effects (KIEs). Studies of the nucleophilic bimolecular substitution (SN2) reaction had the dual purpose of improving our fundamental understanding of molecular reactivity and assessing the ability of kinetic isotope effects to serve as mechanistic tools. LÄS MER