Sökning: "M184I V"

Hittade 4 avhandlingar innehållade orden M184I V.

  1. 1. Detection and significance of drug-resistant HIV-1 minor populations

    Författare :Tobias Bergroth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; antiretroviral treatment; resistance; M184I V; minor populations; selective real-time PCR;

    Sammanfattning : The human immunodeficiency virus (HIV) is the cause of the HIV/AIDS pandemic affecting millions of people around the world. Treatment with antiretroviral drugs, if used properly, leads to a dramatic decrease in virus production in the patient and prevents the onset of AIDS. LÄS MER

  3. 2. Studies of drug resistance in minor HIV quasispecies

    Författare :Halime Ekici; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main objective was to study drug resistance mutations (DRM) in the HIV-1 reverse transcriptase (RT) gene of minor HIV-1 quasispecies, not detectable with standard techniques. Sensitive allele-specific PCR (AS- PCR) and next-generation sequencing (NGS) were developed to study resistance to drugs of relevance in low- and middle-income countries (LMIC); the nucleoside analogue RT inhibitor (NRTI) lamivudine (3TC) and the non-nucleoside RT inhibitors (NNRTIs) efavirenz (EFV) and nevirapine (NVP). LÄS MER

  4. 3. Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance

    Författare :Ujjwal Neogi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis describes the translational genomics of HIV-1subtype C in India from its origin to therapeutic response with the aim to improve our knowledge for better therapeutic and preventive strategies to combat HIV/AIDS. In a systemic approach, we identified the molecular phylogeny of HIV-1 subtypes circulating in India and the time to most recent common ancestors (tMRCA) of predominant HIV-1 subtype C strains. LÄS MER

  5. 4. Deciphering HIV genetic variability and evolution by massive parallel pyrosequencing and bioinformatics

    Författare :Johanna Brodin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 is a virus with a very variable genome and therefore has the ability to adapt to new environments which include escape from immune pressure and suboptimal antiretroviral treatment. Next-generation sequencing (NGS), especially ultra-deep pyrosequencing (UDPS), has enabled in-depth sequencing studies with a previously unattainable resolution. LÄS MER