Sökning: "M-protein"
Visar resultat 1 - 5 av 44 avhandlingar innehållade ordet M-protein.
1. Streptococcal M protein and human C4BP
Sammanfattning : Antigenic variation of surface proteins allows microorganisms to evade the immune system of the infected host. This phenomenon represents an apparent paradox, because the variable protein must retain an important function, while its antigenic properties vary extensively. LÄS MER
2. Resistance to phagocytosis in Streptococcus pyogenes
Sammanfattning : Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. LÄS MER
3. Mechanisms of phagocytosis resistance in Streptococcus pyogenes
Sammanfattning : A distinguishing feature of Streptococcus pyogenes (GAS) is their ability to resist phagocytosis in whole human blood in the absence of type-specific antibodies, a property that is dependent on the expression of the surface associated M proteins. A common characteristic of M proteins is their interaction with a variety of host proteins including the complement regulatory protein factor H (FH) and fibrinogen that plays a key role in coagulation. LÄS MER
4. Streptococcus pyogenes - a manipulator of human defences
Sammanfattning : Streptococcus pyogenes is a major human pathogen with more than 500 000 casualties annually of which at least 163 000 are due to invasive infections. The remainder is due to post-streptococcal complications with rheu¬matic heart disease constituting the majority. S. LÄS MER
5. Studies on streptococcal M proteins. Interactions with IgA and human complement regulators
Sammanfattning : The human pathogenic bacterium Streptococcus pyogenes (group A Streptococcus) expresses several different virulence factors. Of these, the M protein is regarded as one of the most important, because it confers resistance to phagocytosis, allowing the bacterium to multiply in blood. LÄS MER