Sökning: "M Pedersén"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden M Pedersén.

1. 1. ATP-Binding-Cassette Transporters in Biliary Efflux and Drug-Induced Liver Injury

   Författare :Jenny M. Pedersen; Per Artursson; Christel A. S. Bergström; Stefan Oswald; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABC transport protein; Pgp; P-glycoprotein; ABCB1; BCRP; breast cancer resistance protein; ABCG2; MRP2; multidrug resistance-associated protein 2; ABCC2; BSEP; bile salt export pump; ABCB11; sandwich cultured human hepatocytes; SCHH; drug-induced liver injury; DILI; multivariate data analysis; OPLS; Galenisk farmaci; Pharmaceutics;

   Sammanfattning : Membrane transport proteins are known to influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. At the onset of this thesis work, only a few structure-activity models, in general describing P-glycoprotein (Pgp/ABCB1) interactions, were developed using small datasets with little structural diversity. LÄS MER

3. 2. Get it off the ground – Facilitating water-related environmental measures to support agricultural managers in business model innovation processes for sustainability

   Författare :Anna M. Hansson; Jeaneth Johansson; Eja Pedersen; Niklas Karlsson; Richard Fergusson; Högskolan i Halmstad; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sustainable value creation; Business model innovation; Facilitation; Agriculture; Water management; Ecosystem services;

   Sammanfattning : Agricultural businesses, which currently maintain, manage, create, and capture economic value from natural resources on farmland, play an important role in creating sustainable economic, environmental, and social value through maintaining and utilising a variety of ecosystem services in addition to traditional food production. This thesis focuses on ecosystem services that derive from water-related environmental measures (WREMs). LÄS MER

4. 3. G-structures and Families of Isotropic Submanifolds in Complex Contact Manifolds

   Författare :Patrik Hellgren; Sergei Merkulov; Henrik Pedersen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Differential geometry; twistor; G-structures; deformation; MATHEMATICS; MATEMATIK; matematik; Mathematics;

   Sammanfattning : We study a generalized twistor correspondence between irreducible G-structures (with torsion in general) on complex manifolds Z and moduli spaces M of deformations of isotropic homogeneous submanifolds X in complex contact manifolds Y.For any irreducible G-structure on a complex manifold M we present an explicit construction of a contact manifold (a generalized twistor space) Y with contact line bundle L and a family F of isotropic submanifolds X in Y having M as its moduli space. LÄS MER

5. 4. Fluorinated SiC CVD

   Författare :Pontus Stenberg; Erik Janzén; Henrik Pedersen; Angel Yanguas-Gil; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : For the emerging semiconductor material silicon carbide (SiC) used in high power devices, chemical vapor deposition (CVD) is the most prominent method to create the electrically active SiC epitaxial layers in the device. The process of growing such epitaxial layers is to use a hydrocarbon and silane diluted in hydrogen flow through a hot chamber where chemical reactions take place in such manner that Si and C finally deposit on the surface creating epitaxial SiC. LÄS MER

7. 5. Controlled Source Radiomagnetotelluric (CSRMT) Applications in Environmental and Resource Exploration

   Författare :Nazli Ismail; Laust Pedersen; Bulent Tezkan; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Magnetotelluric; radio magnetotelluric; controlled-source tensor magnetotelluric; plane wave; near surface geophysics; sediment; fracture zone; inversion; forward modelling; near field effect; two-dimensional model; three-dimensional model; resolution; Geophysics; Geofysik; Earth Sciences with Specialization Environmental Analysis; geovetenskap med inriktning mot miljöanalys; Hydrology; hydrologi; mineralogi; petrologi och tektonik; Mineral Chemistry; Petrology and Tectonics;

   Sammanfattning : An integrated use of radio magnetotelluric (RMT) and controlled source tensor magnetotelluric (CSTMT) measurements, the so-called CSRMT method, has been employed in environmental and resource exploration studies. A number of case histories, including a groundwater investigation in glacial deposits, a study of fracture zones for geotechnical purposes and a mining exploration study of a copper deposit, are presented in this thesis in order to illustrate the usefulness and capability of the CSRMT method. LÄS MER