Sökning: "M Lindahl"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden M Lindahl.

  1. 1. Deciphering conformational ensembles and communication pathways in biomolecules

    Författare :Annie M. Westerlund; Lucie Delemotte; Erik Lindahl; Kresten Lindorff-Larsen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; Clustering; Machine learning; Network analysis; Calmodulin; KCNQ1; Biological Physics; Biologisk fysik;

    Sammanfattning : Life is constructed by small building blocks called cells. Proteins are the biomolecules within these cells which carry out different functions. Proteins located in the cell membrane, for example, allow for the transport of ions and small molecules, as well as communication, across the cell membrane. LÄS MER

  3. 2. Computational Study of Calmodulin’s Ca2+-dependent Conformational Ensembles

    Författare :Annie M. Westerlund; Erik Lindahl; Lucie Delemotte; Björn Wallner; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; Calmodulin; Free energy estimation; Gaussian mixture models; Spectral clustering; conformational selection; Biological Physics; Biologisk fysik;

    Sammanfattning : Ca2+ and calmodulin play important roles in many physiologically crucial pathways. The conformational landscape of calmodulin is intriguing. Conformational changes allow for binding target-proteins, while binding Ca2+ yields population shifts within the landscape. Thus, target-proteins become Ca2+-sensitive upon calmodulin binding. LÄS MER

  4. 3. Identification of pathophysiological and prognostic biomarkers in different types of myocardial infarction

    Författare :Marcus Hjort; Bertil Lindahl; Kai M. Eggers; Helge Rørvik Røsjø; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardial infarction; biomarker; pathophysiology; prognosis; MINOCA; STEMI; NSTEMI; hjärtinfarkt; biomarkör; patofysiologi; prognos; MINOCA; STEMI; NSTEMI; Cardiology; Kardiologi;

    Sammanfattning : The pathophysiological mechanisms of myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) are largely unknown. Analogous, differences in pathobiology between ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) are incompletely understood. LÄS MER

  5. 4. A Tactile Resonance Sensor System for Detection of Prostate Cancer ex vivo : Design and Evaluation on Tissue Models and Human Prostate

    Författare :Anders P Åstrand; Britt M Andersson; Ville Jalkanen; Olof A Lindahl; E. Göran Salerud; Umeå universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Electronics; elektronik;

    Sammanfattning : Background The most common form of cancer among males in Europe and the USA is prostate cancer, PCa. Surgical removal of the prostate is the most common form of curative treatment. LÄS MER

  7. 5. Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients

    Författare :Karin Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatits C; ribavirin; pharmacokinetics; renal function; plasma concentration; anaemia; population pharmacokinetic analysis; peginterferon; sustained viral response;

    Sammanfattning : Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available are not optimal either regarding cure of disease or risk of side effects. LÄS MER