Sökning: "Lysosomal enzyme"
Visar resultat 21 - 25 av 30 avhandlingar innehållade orden Lysosomal enzyme.
21. Neogenesis and alloxan toxicity in pancreatic islets, with special reference to the transplanted human β-cell
Sammanfattning : The aim of this work was to study whether adult human pancreatic β-cells have the capacity to proliferate in culture and after transplantation to the renal subcapsular space of mice. An immunosuppressive regimen for human islet discordant xenotransplantation to mice was designed. LÄS MER
22. Cellular Effects of Cystatins
Sammanfattning : The exact cellular functions of cystatins are still unknown, and the molecular mechanism leading to their internalization into cells is not yet fully understood. Commonly the cystatins are known to inhibit human lysosomal cysteine proteases (cysteine cathepsins) and it is supposed that this is their primary physiological role. LÄS MER
23. Understanding the dual nature of lysozyme: part villain – part hero : A Drosophila melanogaster model of lysozyme amyloidosis
Sammanfattning : Amyloid proteins are a distinct class of proteins that can misfold into β-sheet rich structures that later mature to form the characteristic species known as amyloid fibrils, and accumulate in tissues in the human body. The misfolding event is often caused by mutations (or outer factors such as changes in pH) that destabilize the native protein structure. LÄS MER
24. Is modulation of glucocerebrosidase a viable new treatment for Parkinson's disease?
Sammanfattning : Background: Parkinson's disease is the second most prevalent neurodegenerative disorder. There are currently no treatments that cure Parkinson’s disease (PD) or slow its progression. There is therefore an urgent need for novel treatments. It was recently discovered that patients with mutations in GBA1 are more likely to develop PD. LÄS MER
25. Assessing the impact of modulating protein degradation pathways in cancer
Sammanfattning : Proteins are macromolecules, essential constituents of the cells with various functions, such as providing structure to the cells, performing biochemical reactions, transporting molecules. The levels of cellular proteins are in a dynamic equilibrium and regulated by their synthesis and degradation rates. LÄS MER