Sökning: "Lysosomal enzyme"
Visar resultat 16 - 20 av 30 avhandlingar innehållade orden Lysosomal enzyme.
16. UVA/B induced redox alterations and apoptosis in human melanocytes
Sammanfattning : Malignant melanoma is one of the most rapidly increasing cancers and accounts for about three-quarter of all skin cancer deaths worldwide. Despite compelling evidence that ultraviolet (UV) irradiation causes melanoma the knowledge how various wavelength spectra affect the balance between proliferation and apoptosis controlling the homeostasis of the melanocyte population is still limited. LÄS MER
17. Old-age muscle atrophy : cellular mechanisms and behavioral consequenses
Sammanfattning : With advancing age, humans and rodents alike lose about one third of the skeletal muscle mass. A process referred to as old-age muscle atrophy or sarcopenia. LÄS MER
18. Neurodegenerative diseases studied in human brain and rodent models
Sammanfattning : Parkinson’s and Alzheimer’s disease are the two most common neurodegenerative diseases world-wide, but are still little understood. Papers in this thesis examine some of the possible pathogenic mechanisms with the help of mouse models and analysis of human post-mortem tissue. LÄS MER
19. Development of Enhanced Analytical Methodology for Lipid Analysis from Sampling to Detection : A Targeted Lipidomics Approach
Sammanfattning : This thesis covers a wide range of analytical method development for lipid analysis in complex biological samples; from sample preparation using pressurized fluid extraction (PFE) and separation with reversed phase capillary liquid chromatography (RP-LC) to detection by electrospray ionization mass spectrometry (ESI/MS) and tandem MS.The requirements for fast, reliable and selective extraction methods with minimal usage of solvents have accelerated the development of new extraction techniques. LÄS MER
20. CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions
Sammanfattning : Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and phosphorylated-tau (P-tau), reflecting brain amyloid, axonal and tangle pathology, respectively. LÄS MER