Sökning: "Lysophosphatidic acid"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Lysophosphatidic acid.

  1. 1. Lysophosphatidic acid : Physiological effects and structure-activity relationships

    Författare :Ulrika K. Nilsson; Samuel Svensson; Karin E. Bornfeldt; Linköpings universitet; []
    Nyckelord :Lysophospholipids pharmacology; physiology; structure-activity relationship; muscle; smooth; drug effects; myometrium; norepinephrine; epinephrine; signal transduction; MEDICINE; MEDICIN;

    Sammanfattning : Lipids havepreviously been considered primarily as building blocks of the cell membrane, but are now also recognized as important cell signaling molecules. Lysophosphatidic acid (LPA) is a glycerophospholipid consisting of a phosphate head group, a linker region, and a lipophilic tail. LÄS MER

  3. 2. Mechanism of F-actin crosslinking by filamin A and the anti-inflammatory functions of plasma gelsolin in bodily fluids

    Författare :Teresia Magnuson Osborn; Göteborgs universitet; []
    Nyckelord :Cytoskeleton; Crosslinking; F-actin; Filamin; Gelsolin; Inflammation; Plasma; Platelet-activating factor; Lysophosphatidic acid; Rheumatoid arthritis;

    Sammanfattning : Gelsolin (GSN) and filamin A (FLNa) are two actin-binding proteins discovered in our laboratory over 30 years ago. GSN is a calcium-activated actin severing and barbed end capping protein that is expressed as both intracellular and extracellular (plasma gelsolin, pGSN) isoforms. LÄS MER

  4. 3. LIPASES AND PHOSPHOLIPASES IN PHOSPHOLIPID SYNTHESIS

    Författare :Carmen Virto; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; transphosphatidylation; acylation; vinyl ester; Phospholipid synthesis; lysophospholipid; kinetics; Biotechnology; Bioteknik;

    Sammanfattning : The synthesis of phospholipids with defined fatty acid and polar head composition catalysed by lipases and phospholipases was investigated. Lipases from Rhizopus arrhizus and Candida antarctica were used for the direct acylation of DL-a-glycerophosphate and L-a-glycerophosphatidylcholine, with different fatty acids. LÄS MER

  5. 4. Impact of genetic and environmental factors in intestinal inflammation

    Författare :Oscar Eduardo Diaz Perez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The gastrointestinal tract, is continuously exposed to a wide variety of stimuli, including dietary-derived metabolites, environmental compounds and the microbiota. Since these antigens can be beneficial or detrimental for the organism, proper sensing of the luminal content is essential for orchestrating both pro-inflammatory and tolerogenic immune responses on demand and therefore, ensure the establishment of intestinal homeostasis. LÄS MER

  7. 5. Platelet Adhesion to Proteins in Microplates : Applications in Experimental and Clinical Research

    Författare :Andreas Eriksson; Per Whiss; Håkan Wallén; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; platelet adhesion; platelet assay; synergistic activation; thrombosis; anti-platelet treatment; Pharmacology; Farmakologi;

    Sammanfattning : Platelets are crucial for prevention of blood loss after vessel injury. Platelet adhesion to disrupted vessel walls is mediated by receptors such as the GPIb-IX-V complex that binds von Willebrand factor and the collagen-binding integrin α2β1. LÄS MER