Sökning: "Lymphatic vasculature"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Lymphatic vasculature.

1. 1. Lymphatic Vascular Morphogenesis : From Progenitors to Functional Vessels

   Författare :Nina Daubel; Taija Mäkinen; Markus Affolter; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphatic vasculature; morphogenesis; lymphvasculogenesis; mesentery; lymphatic capillary;

   Sammanfattning : The lymphatic vasculature is an important part of the circulatory system and crucial for normal functioning and maintenance of tissues. Yet, our understanding of the processes underlying lymphatic development and homeostasis are surprisingly limited. LÄS MER

3. 2. Organ-specific mechanisms of vascular development in the mesentery

   Författare :Yang Zhang; Taija Mäkinen; Wiebke Herzog; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lymphatic vasculature; mesentery; hemogenic endothelium; lymphvasculogenesis; endothelial integrity; platelet; blood-filled lymphatic vessel; morphogenesis and maturation; compensation;

   Sammanfattning : Understanding how the vascular systems are formed has significant clinical importance. General mechanisms underlying vascular development have been extensively studied during the past decades. However, the mechanisms regulating the development and function of the blood and lymphatic vessels in specific organs are poorly understood. LÄS MER

4. 3. The elephant in the cell : A multifaceted undertaking to uncover the molecular principles behind lymphatic endothelial cell identity

   Författare :Virginia Panara; Katarzyna Koltowska; Taija Mäkinen; Marcel den Hoed; Sarah de Val; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lymphatic endothelium; Development; Epigenetic; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

   Sammanfattning : The lymphatic vascular network is composed of a series of blind ended vessels, and is involved in physiological functions such as fluid homeostasis, lipid metabolism and immune trafficking. Despite lymphatic endothelial cells being derived from multiple organs, they share common molecular denominators, including the expression of the transcription factor Prox1. LÄS MER

5. 4. From endothelial cells to the vascular network : How cell migration and proliferation are orchestrated to build lymphatic vessels

   Författare :Di Peng; Katarzyna Koltowska; Vermot Julien; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lymphangiogenesis; Cell migration; Zebrafish; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

   Sammanfattning : Lymphatic endothelial cells (LECs) migrate across body to form a branched network, which is crucial for fluid drainage and immune cell trafficking of the tissues. However, the molecular mechanisms behind the spatiotemporal regulation and fine-tuning of LEC migration remain largely unknown. LÄS MER

7. 5. Studies of the tumor-vasculature interface : role of TGF-beta 1-induced epithelial to mesenchymal transition

   Författare :Mei-Fong Pang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tumor metastasis is a complex multistep process. Among key steps that occur during metastatic spread are acquisition of tumor cell motility, intravasation of tumor cells into blood or lymphatic vessels and extravasation of tumor cells at distal sites. However, the precise mechanisms that govern these metastatic steps remain elusive. LÄS MER