Sökning: "Lymphatic endothelial cells LECs"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Lymphatic endothelial cells LECs.

  1. 1. Lymphatic Vascular Morphogenesis : From Progenitors to Functional Vessels

    Författare :Nina Daubel; Taija Mäkinen; Markus Affolter; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphatic vasculature; morphogenesis; lymphvasculogenesis; mesentery; lymphatic capillary;

    Sammanfattning : The lymphatic vasculature is an important part of the circulatory system and crucial for normal functioning and maintenance of tissues. Yet, our understanding of the processes underlying lymphatic development and homeostasis are surprisingly limited. LÄS MER

  3. 2. From endothelial cells to the vascular network : How cell migration and proliferation are orchestrated to build lymphatic vessels

    Författare :Di Peng; Katarzyna Koltowska; Vermot Julien; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lymphangiogenesis; Cell migration; Zebrafish; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

    Sammanfattning : Lymphatic endothelial cells (LECs) migrate across body to form a branched network, which is crucial for fluid drainage and immune cell trafficking of the tissues. However, the molecular mechanisms behind the spatiotemporal regulation and fine-tuning of LEC migration remain largely unknown. LÄS MER

  4. 3. The elephant in the cell : A multifaceted undertaking to uncover the molecular principles behind lymphatic endothelial cell identity

    Författare :Virginia Panara; Katarzyna Koltowska; Taija Mäkinen; Marcel den Hoed; Sarah de Val; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lymphatic endothelium; Development; Epigenetic; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

    Sammanfattning : The lymphatic vascular network is composed of a series of blind ended vessels, and is involved in physiological functions such as fluid homeostasis, lipid metabolism and immune trafficking. Despite lymphatic endothelial cells being derived from multiple organs, they share common molecular denominators, including the expression of the transcription factor Prox1. LÄS MER

  5. 4. Organ-specific mechanisms of vascular development in the mesentery

    Författare :Yang Zhang; Taija Mäkinen; Wiebke Herzog; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lymphatic vasculature; mesentery; hemogenic endothelium; lymphvasculogenesis; endothelial integrity; platelet; blood-filled lymphatic vessel; morphogenesis and maturation; compensation;

    Sammanfattning : Understanding how the vascular systems are formed has significant clinical importance. General mechanisms underlying vascular development have been extensively studied during the past decades. However, the mechanisms regulating the development and function of the blood and lymphatic vessels in specific organs are poorly understood. LÄS MER

  7. 5. The role of the lymph node stroma in cancer and aging

    Författare :Tove Bekkhus; Maria H. Ulvmar; Timothy P. Padera; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymph node; Stroma; High endothelial venule HEV ; Lymphatic endothelial cells LECs ; Breast cancer; Metastasis; Lipomatosis; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The function of the lymph node (LN) stroma is crucial for the induction of an adaptive immune response. The stroma includes lymphatic vessels, high endothelial venules (HEVs) and mesenchymal cells (MCs). In this thesis, I have been investigating the role of the LN stroma in cancer and aging. LÄS MER