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1. 1. Molecular mechanisms underlying the activation of ALC1 nucleosome remodeling

   Författare :Luka Bacic; Sebastian Deindl; Stefan D. Knight; Lari Lehtiö; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ALC1; CHD1L; nucleosome; ADP-ribosylation; chromatin; remodeling; PARP1; HPF1; DNA damage; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

   Sammanfattning : Packaging DNA into chromatin represses essential DNA-based processes, such as transcription, DNA replication, and repair. To change the accessibility of DNA, cells have evolved a set of enzymes referred to as chromatin remodelers that act on the basic repeat unit of chromatin,  the nucleosome. LÄS MER