Sökning: "Lp-PLA2"

Hittade 5 avhandlingar innehållade ordet Lp-PLA2.

  1. 1. Lipoprotein-associated phospholipase A2 (Lp-PLA2) Impact and role as cardiovascular risk marker

    Författare :Margaretha Persson; Internmedicin - epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiovascular disease; cohort study; epidemiology; Lp-PLA2; PLA2G7 gene; metabolic syndrome; risk factor; stroke;

    Sammanfattning : Lipoprotein-associated phospholipase A2 (Lp-PLA2) is today considered a novel specific vascular inflammatory biomarker. The general aim of this thesis was to study the role and impact of Lp-PLA2 as cardiovascular (CV) risk marker in an epidemiologic perspective. LÄS MER

  3. 2. Detecting the Vulnerable Plaque

    Författare :Andreas Edsfeldt; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; Carotid plaque; Inflammation; Diabetes; LpPLA2; suPAR; Cytokines; Lipids;

    Sammanfattning : Myocardial infarction and stroke, mainly caused by a rupture of an atherosclerotic plaque, are two of the most common causes of mortality and morbidity in the world. Previous studies have pointed out inflammation, driven by inflammatory lipids, as the keystone in the formation of the rupture prone vulnerable plaque. LÄS MER

  4. 3. Molecular and psychosocial risk factors for cardiovascular disease

    Författare :Iffat Rahman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease (CVD) is the leading cause of mortality globally, and a major contributor to disability. There exist several well-established CVD risk factors, many of which are used in clinical practice. Nonetheless, these risk factors do not fully explain why certain individuals develop CVD. LÄS MER

  5. 4. Lyso-PC and macrophage interplay. Scavenging through the fatty side of atherosclerosis

    Författare :Katarina Berg; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Atherosclerosis is triggered by LDL entrapment in the vessel wall. Oxidation and enzymatic processing of LDL give rise to inflammatory mediators such as lyso-PC. These inflammatory mediators attract monocytes into the vessel wall where they differentiate into macrophages. The macrophages adopt different phenotypes depending on the environment. LÄS MER

  7. 5. Carotid stenosis: aspects on progression, stabilization and follow-up

    Författare :Giuseppe Asciutto; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atherosclerosis; carotid plaque; echogenity; beta-blockers; inflammation; antibodies anti oxLDL;

    Sammanfattning : Cardiovascular (CV) atherosclerotic diseases are the leading cause of death in Western nations. The presence of a carotid plaque, the degree of carotid stenosis as well as the rate of progression of carotid disease has been shown to be independent predictive factors for future ischemic events. LÄS MER