Sökning: "Local anaesthetics drugs"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Local anaesthetics drugs.

  1. 1. Microextraction by packed sorbent of drugs and peptides in biological fluids

    Författare :Seyed Mosayeb Daryanavard; Mohamed Abdel-Rehim; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; MEPS; Local anaesthetics drugs; Peptides; Analytical Chemistry; analytisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Sample preparation as the first step in an analytical procedure has an important role, particularly in bioanalysis, because of the complexity of biological samples (blood plasma and urine). Biological matrix such as plasma and blood contains proteins, organic and inorganic salts, acids, bases and various organic compounds with similar chemistry to the analytes of interest. LÄS MER

  2. 2. Long acting local anaesthetics - a study in rats

    Författare :Henrik Dyhre; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; in vivo and effect kinetics; Comparison of in vitro; Neuro toxicity; Infraorbital nerve block; Sciatic nerve block; Lipid depot formulation;

    Sammanfattning : Local anaesthetics provide excellent pain relief after central and peripheral nerve blocks. However, in many clinical situations there is an insufficient duration of action to allow effective treatment of long-term pain with single injection techniques. This problem became the focus of the present studies. LÄS MER

  3. 3. On paediatric regional anaesthesia : The use of paravertebral blockade, aspects on plasma protein binding, and systemic toxicity of local anaesthetics

    Författare :PA Lönnqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Anesthesia; regional; paravertebral Children; infants Local anesthetics; bupivacaine; lidocaine Pharmacokinetics Plasma protein binding Side effects Toxicity.PA Lönnqvist: On paediatric regional anaesthesia: The use of paravertebral blockade; aspec;

    Sammanfattning : Paediatric regional anaesthesia has gained widespread popularity during recent yearsbecause of an excellent potential for intra- and postoperative pain relief and reduction of thesurgically induced stress response. The aim of the present thesis was to adapt and develop thetechnique of paravertebral blockade (PVB) for the safe use in paediatric patients and also toinvestigate aspects on plasma protein binding and toxicity of local anaesthetic drugs whichmight be of importance in the special settings of paediatric anaesthesia. LÄS MER

  4. 4. APPLICATION OF NEW TECHNOLOGY: MEPS AND LC-MS/MS FOR DETERMINATION OF THERAPEUTIC DRUGS

    Författare :Rana Said; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Bioanalysis most often requires an extraction procedure to isolate the target compounds from a complex matrix. The aim of this work was to evaluate microextraction in packed syringe (MEPS) performance as a sample preparation technique by developing new analytical methods for different categories of compounds utilizing MEPS in combination with LC-MS/MS. LÄS MER

  5. 5. Ropivacaine : An experimental and clinical study with special reference to analgesic, circulatory and antiinflammatory effects

    Författare :Ingemar Cederholm; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Aims of the study: 1. to compare ropivacaine, a new long-acting amino-amide local anaesthetic drug, and bupivacaine (with/without adrenaline) concerning dermal analgesia and local vascular effects, 2. to design a suitable test procedure to evaluate changes in skin blood flow after intradermal injection of local anaesthetics, 3. LÄS MER