Sökning: "Liver X receptor"

Visar resultat 1 - 5 av 56 avhandlingar innehållade orden Liver X receptor.

  1. 1. Estrogen and liver X receptors in human disease

    Författare :Maria Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen Receptor; Liver X Receptor; polymorphism; Bulimia Nervosa; SNP; BMI; obesity; expression levels; T2D.;

    Sammanfattning : The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated several pathophysiological conditions in which the NRs are involved. LÄS MER

  3. 2. Insulin-like Growth Factor-I (IGF-I) and Interleukin-6 (IL-6) regulate body fat

    Författare :Kristina Wallenius; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; insulin-like growth factor I IGF-I ; interleukin-6 IL-6 ; growth hormone GH ; GH releasing factor GHRF ; GH secretagogue GHS ; receptor; leptin; insulin; glucose; intracerebroventricular ICV ; dual-energy X-ray absorptiometry DXA ; indirect calorimetry.;

    Sammanfattning : The aim of this thesis was to investigate the role of insulin-like growth factor-I (IGF-I) and interleukin-6 (IL-6) in the regulation of metabolism and body fat mass. Circulating IGF-I is mainly liver derived, while a large part of circulating IL-6 is produced by adipose tissue. LÄS MER

  4. 3. Hyaluronan receptors of liver endothelial cells, their purification and characterisation

    Författare :Peter A. G. McCourt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; hyaluronan; scavenger receptors; ICAM-1; liver endothelial cells; Biokemi; Biochemistry; Biokemi; fysiologi; Physiology;

    Sammanfattning : Hyaluronan (HA) is a polysaccharide common throughout the connective tissues. and is found at low concentrations in the blood. The major site of its clearance is via an endocytic receptor on liver endothelial cells (LEC). This process is vital, as excessive serum levels of HA lead to clotting disorders and overly viscous blood. LÄS MER

  5. 4. Thyroid hormone receptors in liver metabolism

    Författare :Hjalmar Gullberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Thyroid hormone has a profound impact on mammalian metabolism; hypothyroidism causes decreased metabolic rate and increased serum cholesterol levels. One major target organ for the hormone is the liver, the most important metabolic organ in mammals, that balances anabolism of carbohydrates and lipids against catabolism. LÄS MER

  7. 5. Expression and function of vascular estrogen receptors alpha and beta

    Författare :Min Liang; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetologi; diabetology; Endokrinologi; sekretion; ubiquitin-proteasome pathway; MIP-2; MCP-1; iNOS; estrogen receptor knockout; estrogen receptor; aorta; estrogen;

    Sammanfattning : Estrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. LÄS MER