Sökning: "Liquid Chromatography Tandem Mass Spectrometry"

Visar resultat 6 - 10 av 75 avhandlingar innehållade orden Liquid Chromatography Tandem Mass Spectrometry.

  1. 6. Analysis of lignin monomers and oligomers in technical lignins using chromatography and mass spectrometry

    Författare :Jens Prothmann; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lignin; Mass spectromery; Chromatography;

    Sammanfattning : Lignin is the most abundant aromatic biopolymer on earth and has the potential to play an important role in the transition from an oil-based refinery to a biorefinery-based industry. The isolation of lignin from the biomass can be achieved by several different technical processes and isolated lignins are referred to as technical lignins in literature. LÄS MER

  3. 7. Isocyanates, Amines and Alkanolamines : Sampling, Chromatography and Detection

    Författare :Jakob B. Riddar; Marianne Dalene; Gunnar Skarping; Daniel Karlsson; Håkan Westberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Air-sampling; Isocyanates; Aromatic amines; Aliphatic amines; Alkanolamines; Hydrophilic Interaction Liquid Chromatography; Dry Denuder-Filter sampler; Liquid Chromatography–tandem Mass Spectrometry; Polyurethane Foam Extraction; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Isocyanates, aromatic-, aliphatic- and alkanolamines are commonly used in the industry today. Millions of workers in Europe are exposed. The most frequent health symptoms are respiratory and dermal disorder. Due to the health risk most of the compounds in this thesis are regulated by authorities and have occupational exposure limits (OELs). LÄS MER

  4. 8. Chemical Derivatization in Combination with Liquid Chromatography Tandem Mass Spectrometry for Detection and Structural Investigation of Glucuronides

    Författare :Matilda Lampinen Salomonsson; Mikael Hedeland; Ulf Bondesson; Calle Nilsson; Uppsala universitet; []
    Nyckelord :Pharmaceutical chemistry; Derivatization; mass spectrometry; glucuronide; drug metabolism; increased sensitivity; structural investigation; 2-chloro-1-methylpyridinium iodide CMPI ; 1-ethyl-3- 3-dimethylaminopropyl -carbodiimide EDC ; 2-picolylamine PA ; 1; 2-dimethylimidazole-4-sulfonyl chloride DMISC ; Farmaceutisk kemi;

    Sammanfattning : This thesis presents novel approaches for structural investigation of glucuronides using chemical derivatization in combination with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn).Today, LC-ESI-MSn is the dominant technique for quantitative as well as qualitative analyses of metabolites, due to its high sensitivity and selectivity. LÄS MER

  5. 9. Development of Enhanced Analytical Methodology for Lipid Analysis from Sampling to Detection : A Targeted Lipidomics Approach

    Författare :Giorgis Isaac; Jonas Bergquist; Karin Markides; Monica Waldebäck; William Christie; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; electrospray ionization; lipids; liquid chromatography; mass spectrometry; pesticides; phosphatidylcholine; pressurized fluid extraction; sphingomyelin; sulfatides; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : This thesis covers a wide range of analytical method development for lipid analysis in complex biological samples; from sample preparation using pressurized fluid extraction (PFE) and separation with reversed phase capillary liquid chromatography (RP-LC) to detection by electrospray ionization mass spectrometry (ESI/MS) and tandem MS.The requirements for fast, reliable and selective extraction methods with minimal usage of solvents have accelerated the development of new extraction techniques. LÄS MER

  7. 10. Chemometrics : Unravelling information from complex data generated by modern instruments

    Författare :Pedro F. M. de Sousa; Magnus Åberg; Johan Trygg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Chromatography; Mass spectrometry; DIA; PCA; PLS; Experimental Design; DNA; adductomics; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Chemometrics is a discipline dedicated to solving problems arising from complicated analytical systems, combining statistics, mathematics, and computational programming languages.This thesis is based on the work developed in four scientific projects published as papers in scientific journals. LÄS MER